Particulate Materials: Synthesis, Characterisation, Processing and Modelling (Special Publications) - Hardcover

Hardcover

ISBN 10: 184973366X ISBN 13: 9781849733663

Verlag: Royal Society of Chemistry, 2011

Inhaltsangabe

Naturally occurring or manufactured through chemical and/or physical processes, particulate materials are substances consisting of individual particles which have significance to the global economy, society and environments. Due to the diversity and intrinsic nature, manufacturing, handling and processing of particulate materials still face numerous challenges. Aimed at addressing these challenges, this book contains  a selection of papers discussing the state-of-the-art research in particulate materials science that were presented at the UK–China Particle Technology Forum III held at Birmingham, UK in 2011.
Classified into four distinct topics namely synthesis, characterisation, processing and modelling, the chapters showcase the advances in these areas including a range of advanced synthesis methods for example, spray-pyrolysis, supercritical fluid synthesis assisted with ultrasound, continuous synthesis using supercritical water, hydrothermal synthesis of nano-particulate materials and jet milling. For characterisation, various methods for characterising particulate materials at both particle and system levels are introduced and how these properties affect the behaviour of particulate materials in various processes, such as inhalation, filling, and consolidation, are discussed. In the processing section, recent advances such as capsule filling, micro-dosing, dry granulation, roll compaction, milling, and more are presented. The last section concerns mathematical and numerical modelling in particulate materials, for which the book includes both analytical methods and advanced numerical methods, such as discrete element methods (DEM), computational fluid dynamics (CFD), lattice Boltzmann methods (LBM), coupled DEM/CFD and DEM/LBM, and their applications.
Particulate Materials is aimed at research communities dealing with these diverse materials, and scientists and engineers in powder handling industries, such as pharmaceutical, food, fine chemical and detergents.

Über diesen Titel

Über die Autorin bzw. den Autor

Chuan-Yu (Charley) Wu is a senior lecturer at the School of Chemical Engineering at University of Birmingham and has research interests in understanding and modelling the behaviour of particulate materials during the manufacturing processes for pharmaceutical and other particulate products at microscopic and macroscopic levels. In particular, he is interested in developing models for predicting the properties of products based on the properties of particles and individual constituents. Wei Ge is Associate Professor at the Institute of Process Engineering, Academia Sinica, Chinese Academy of Sciences, Beijing. His research interests are diverse from particle methods for the simulation of multiphase systems, multi-scale analysis and non-equilibrium statistical mechanics of complex flows in chemical engineering to software platform and system architecture for massive parallel processing of discrete dynamics systems. Since 2002 Ge has been a council member of the Chinese Society of Particuology.

Von der hinteren Coverseite

Naturally occurring or manufactured through chemical and/or physical processes, particulate materials are substances consisting of individual particles which have significance to the global economy, society and environments. Due to the diversity and intrinsic nature, manufacturing, handling and processing of particulate materials still face numerous challenges. Aimed at addressing these challenges, this book contains a selection of papers discussing the state-of-the-art research in particulate materials science that were presented at the UK–China Particle Technology Forum III held at Birmingham, UK in 2011.
Classified into four distinct topics namely synthesis, characterisation, processing and modelling, the chapters showcase the advances in these areas including a range of advanced synthesis methods for example, spray-pyrolysis, supercritical fluid synthesis assisted with ultrasound, continuous synthesis using supercritical water, hydrothermal synthesis of nano-particulate materials and jet milling. For characterisation, various methods for characterising particulate materials at both particle and system levels are introduced and how these properties affect the behaviour of particulate materials in various processes, such as inhalation, filling, and consolidation, are discussed. In the processing section, recent advances such as capsule filling, micro-dosing, dry granulation, roll compaction, milling, and more are presented. The last section concerns mathematical and numerical modelling in particulate materials, for which the book includes both analytical methods and advanced numerical methods, such as discrete element methods (DEM), computational fluid dynamics (CFD), lattice Boltzmann methods (LBM), coupled DEM/CFD and DEM/LBM, and their applications.
Particulate Materials is aimed at research communities dealing with these diverse materials, and scientists and engineers in powder handling industries, such as pharmaceutical, food, fine chemical and detergents.

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Particulate Materials

Synthesis, Characterisation, Processing and Modelling

By Chuan-Yu Wu, Wei Ge

The Royal Society of Chemistry

Copyright © 2012 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-84973-366-3

Contents

Synthesis, 
Production of resveratrol nanoparticles using solution enhanced dispersion in supercritical CO2 with enhanced mass transfer by ultrasound H.Y. Jin and Y.P. Zhao, 3, 
A self-assembly mechanism of cuprous oxide nanoparticles in aqueous colloidal solutions Y. Bai, T. Yang, G. Cheng and R. Zheng, 10, 
One-step synthesis of mesoporous sulfated zirconia nanoparticles with anion template L. Y. Zhang, H. Wang, S. W. Xu, C. Y. Han, Y. Y. Zhang, D. Q. Du, J Y. Li and Y. M Luo, 17, 
Rapid and continuous synthesis of LiFePO4 and LiFePO4/C nanoparticles in supercritical water X. Song and Y.P. Zhao, 23, 
Hydrothermal synthesis of TiO2 nanoparticles: process modelling and experimental validation M. Chen, C. Y. Ma, T. Mahmud, T. Lin and X. Z. Wang, 28, 
Spherical gamma alumina nano-powders produced from aluminium salts boehmite sol by spay-pyrolysis processes X. Wu, S. Ye and Y. Chen, 34, 
A facile route for rapid synthesis of mesoporous SBA-16 silica S. W. Xu, H.P. Pu, H. Wang, L. Y. Zhang, C. Y. Han, D. Q. Du, Y. Y. Zhang and Y. M. Luo, 40, 
The underlying mechanism of hydrothermal stability for ordered mesoporous molecular sieves without micropores H. P. Pu, H. Wang, S. X. Xu, C. Y. Han, L. Y. Zhang, Y. Y. Zhang, D. Q. Du and Y. M. Luo, 46, 
Preparation of rod-shape sillimanite powder using a jet mill G. Du, W. Cao and L. Liao, 52, 
Surface modification of diatomite with titanate and its effects on the properties of reinforcing NR/SBR blends J.H. Liao, G.X. Du, L.F. Mei, W.J. Guo, R.F. Zuo, 59, 
Characterisation, 
Estimation of 3d faceted growth rates of potash alum crystals in a hot-stage reactor using online 2d images C. Y. Ma, J. Wan and X. Z. Wang, 69, 
A novel approach to quantifying and scaling air current segregation from experiments to industrial silos S. Zigan, 76, 
Investigation into the degree of variability in the solid state properties of common pharmaceutical excipients - microcrystalline cellulose J.F. Gamble, W.-S. Chiu, V. Gray, H. Toale, M. Tobyn and Y. Wu, 82, 
Structural transformation in a frictional granular system Q.C. Sun, G.H. Zhang, Z. W. Bi and J. G. Liu, 92, 
Cyclic loading characteristics of a 2D granular assembly Z. W. Bi, Q.C. Sun, J. Fen, and J.G. Liu, 97, 
The impact of dry granulation on detergent powder properties A. Hart and C.-Y. Wu, 102, 
Processing, 
The effect of carrier particle size on adhesion, content uniformity and inhalation performance of budesonide using dry powder inhalers W. Kaialy, H. Larhrib and A. Nokhodchi, 113, 
The control of microdispensed mean dose of INHALAC®70 by varying the time of vibration in an acoustic micro-dosing system Z. Li, L. Pan, P. N. Balani and S. Yang, 120, 
The effect of signal amplitude of an ultrasonic vibration controlled metering, device on micro-dispensing of inhalation grade lactose Z. Li, L. Pan, P.N. Balani and S. Yang]TP1 TP1[125, 
Capsule filling performance of powdered formulations in relation to flow characteristics T. Freeman, V. Moolchandani, S. W. Hoag and X. Fu, 131, 
The role of nozzle size of an acoustic vibration controlled micro-dosing system on micro-dispensing of INHALAC®70 Z. Li, L. Pan, P. N. Balani and S. Yang, 137, 
The influence of flow properties on roll compaction behaviour of pharmaceutical blends N. H. Hamidi and C.-Y. Wu, 142, 
An experimental investigation of dry granulation C.H. Goey, K. Lu and C.-Y. Wu, 148, 
Experimental investigation of milling of roll compacted ribbons S. Yu, B. Gururajan, G. Reynolds, R. Roberts, M.J. Adams and C.-Y. Wu, 158, 
Effect of swirl on separation performance of a new spray granulation tower M. Liu, Y. Mao, J. Wang and J. Wang, 167, 
Combined effects of acoustic wave and gas-solid jet on agglomeration of inhalable particles from coal combustion plant Z. YANG and Q. GUO, 174, 
The effect of cyclone height on flow field and separation performance C. Gao, G. Sun, J. Yang, R. Dong and J. Liu, 180, 
Influence of fluidization conditions on sticking time during reduction of Fe2O3 particles with CO B. Zhang, Z. Wang, X. Gong and Z. Guo, 190, 
Solids friction factor for horizontal dense phase pneumatic conveying of pulverised coal X. Guo, W. Li, H. Lu, X. Cong and X. Gong, 198, 
Dense phase pneumatic conveying of biomass and biomass/coal blends at high pressures C. He, J. Wang, H. Ni, X. Chen, Y. Xu, H. Zhou, Y. Xiong and X. Shen, 204, 
Modelling, 
The influence of wetting on the buoyancy of particles J. Bowen, D. Cheneler, M.C.L. Ward and M.J. Adams, 213, 
Transport phenomena in packed beds R. Ocone, 219, 
Incorporating the wedging effect in a new packing model A.K.H. Kwan, K. W. Chan and V. Wong, 227, 
A discrete element model for contact electrification C. Pei, D. England, S. Byard, H. Berchtold and C.-Y. Wu, 233, 
Large-scale discrete element simulations of granular materials J. G. Liu, Q.C. Sun, Q.K. Liu and F. Jin, 240, 
Discrete element modelling of a mole sampling mechanism S. Zigan and A. Hennessey, 245, 
Study of granular material multi-scale characteristics from complex network perspective J. Wu, F. Liu, Y. Dai, Z. Wang and D. Hu, 250, 
A lattice Boltzmann-lattice gas automata model for analysing the structure and efficiency of deposited particulate matter on fibrous filters H. Wang, H. Zhao, Z. Guo and C. Zheng, 258, 
Numerical simulation of a pipe leakage problem with cohesive particles X. Cui, J. Li, A. Chan and D. Chapman, 265, 
CFD investigation of plug flow dense phase pneumatic conveying with a step in pipeline bore D. McGlinchey, A. Cowell and R. Crowe, 271, 
CFD simulation of fluid flow and heat transfer in a counter-current reactor system under supercritical conditions C. Y. Ma, T. Mahmud, X. Z. Wang, C. Tighe and J.A. Darr, 278, 
Numerical investigation of turbulent heat transfer enhancement in helically coiled tubes using AL2O3 nanofluid A.M Elsayed, R.K. AL-Dadah, S. Mahmoud and A. Mahrous, 285, 
Subject Index, 294, 

CHAPTER 1

PRODUCTION OF RESVERATROL NANOPARTICLES USING SOLUTION ENHANCED DISPERSION IN SUPERCRITICAL CO2 WITH ENHANCED MASS TRANSFER BY ULTRASOUND

H.Y. Jin and Y.P. Zhao

School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan RD. Shanghai 200240, China

Email: ypzhao@sjtu.edu.cn

1. INTRODUCTION

About 40% of the drugs or drug candidates are regarded as biopharmaceutic class II - low solubility and high permeability. Moreover, some side effects appear after the administration of such drugs in the gastrointestinal tract because of their toxicity, low bioavailability and poor absorption. To solve these problems, reducing the size of these drugs into micron or nanoparticles is a promising and effective way. The dissolution rate of these drugs can be enhanced due to increased surface area and chemical potential. Many methods and techniques of reducing the size of ingredients in the pharmaceutical industry were established. Among them, the techniques based on supercritical fluids (SCF) as an antisolvent are considered the advanced approaches to obtain size controllable, tiny and free-solvent residual particles. These techniques consist of several main processes, such as supercritical antisolvent precipitation...

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2011
• Sprache: Englisch
• ISBN 10: 184973366X
• ISBN 13: 9781849733663
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 296
• Herausgeber: Wu Chuan-yu, Ge Wei
• Kontakt zum Hersteller: preigu GmbH & Co. KG; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; Niedersachsen; 49078; Deutschland