B Vitamins and Folate: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus, 4) - Hardcover

Hardcover

ISBN 10: 1849733694 ISBN 13: 9781849733694

Verlag: Royal Society of Chemistry, 2012

Inhaltsangabe

B Vitamins and Folate covers thiamine, riboflavin, pantothenic acid, pyridoxine, biotin, cobalamin and folate. The book begins with an overview covering the historical context of B vitamins, disease and fortification effects. Coverage then includes chemistry, biochemistry and metabolism across the vitamins and related compounds; analysis including spectrofluorimetry, isotope dilution mass spectrometry, chromatography; and finishes with the functional effects in humans including in strokes, epilepsy, dementia and kidney disease. Written by an expert team, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.

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Über die Autorin bzw. den Autor

Victor Preedy is currently Professor of Nutritional Biochemistry and Director of Genomics Centre, King's College London and Professor of Clinical Biochemistry at King's College Hospital London. After graduating with a BSc degree in Physiology with Pharmacology and Biology, Professor Preedy carried out a period of research on protein metabolism in the Department of Nutrition at the London School of Hygiene and Tropical Medicine. After the successful award of his PhD he studied aspects of cardiac protein metabolism at the National Heart Hospital. After 4 years, he then moved to the MRC Clinical Research Centre in Harrow, which was followed by his appointment as a lecturer to Kings College in 1988. He was promoted to Reader in 1995 and Professor in 2003. Professor Preedy has published over 550 articles, which includes over 160 peer-reviewed manuscripts based on original research and 90 reviews as well as 35 books.

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B Vitamins and Folate covers thiamine, riboflavin, pantothenic acid, pyridoxine, biotin, cobalamin and folate. The book begins with an overview covering the historical context of B vitamins, disease and fortification effects. Coverage then includes chemistry, biochemistry and metabolism across the vitamins and related compounds; analysis including spectrofluorimetry, isotope dilution mass spectrometry, chromatography; and finishes with the functional effects in humans including in strokes, epilepsy, dementia and kidney disease.
Written by an expert team and delivering high quality information, this book provides a fascinating insight into this area of health and nutritional science. It will bridge scientific disciplines so that the information is more meaningful and applicable to health in general. Part of a series of books, it is specifically designed for chemists, analytical scientists, forensic scientists, food scientists, dieticians and health care workers, nutritionists, toxicologists and research academics. Due to its interdisciplinary nature it could also be suitable for lecturers and teachers in food and nutritional sciences and as a college or university library reference guide.

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B Vitamins and Folate

Chemistry, Analysis, Function and Effects

By Victor R. Preedy

The Royal Society of Chemistry

Copyright © 2013 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-84973-369-4

Contents

B Vitamins and Folate in Context, 
Chapter 1 Historical Context of Vitamin B Hideyuki Hayashi, 3, 
Chapter 2 B Vitamins and Disease Jutta Dierkes and Ottar Nygård, 21, 
Chapter 3 Vitamins and Folate Fortification in the Context of Cardiovascular Disease Prevention Alexios S. Antonopoulos, Cheerag Shirodaria and Charalambos Antoniades, 35, 
Chapter 4 The Importance of Vitamins in Biochemistry and Disease as Illustrated by Thiamine Diphosphate (ThDP) Dependent Enzymes Shinya Fushinobu and Ryuichiro Suzuki, 55, 
Chemistry and Biochemistry, 
Chapter 5 The Chemistry, Biochemistry and Metabolism of Thiamin (Vitamin B1) Lucien Bettendorff, 71, 
Chapter 6 Chemistry and Biochemistry of Riboflavin and Related Compounds Mariana C. Monteiro and Daniel Perrone, 93, 
Chapter 7 The Chemistry and Biochemistry of Niacin (B3) Asdrubal Aguilera-Méndez, Cynthia Fernández-Lainez, Isabel Ibarra-González and Cristina Fernandez-Mejia, 108, 
Chapter 8 The Chemistry of Pantothenic Acid (Vitamin B5) Katsumi Shibata and Tsutomu Fukuwatari, 127, 
Chapter 9 The Chemistry and Biochemistry of Vitamin B6: Synthesis of Novel Analogues of Vitamin B6 Dajana Gaso Sokac, Spomenka Kovac, Valentina Busic, Colin R. Martin and Jasna Vorkapic Furac, 135, 
Chapter 10 Biochemistry of Biotin Janos Zempleni, Wei Kay Eng, Mahendra P. Singh and Scott Baier, 146, 
Chapter 11 The Chemistry of Folate Abalo Chango, 158, 
Chapter 12 The Chemistry of Cobalamins Alexios S. Antonopoulos and Charalambos Antoniades, 164, 
Analysis, 
Chapter 13 Assay of B Vitamins and other Water-soluble Vitamins in Honey Marco Ciulu, Nadia Spano, Severyn Salis, Maria I. Pilo, Ignazio Floris, Luca Pireddu and Gavino Sanna, 173, 
Chapter 14 Analytical Trends in the Simultaneous Determination of Vitamins B1, B6 and B12 in Food Products and Dietary Supplements Anna Lebiedzinska and Marcin L. Marszall, 195, 
Chapter 15 Spectrofluorimetric Analysis of Vitamin B1 in Pharmaceutical Preparations, Bio-fluid and Food Samples Sang Hak Lee, Mohammad Kamruzzaman and Al-Mahmnur Alam, 210, 
Chapter 16 Measurement of Thiamine Levels in Human Tissue Natalie M. Zahr, Mary E. Lough, Young-Chul Jung and Edith V. Sullivan, 227, 
Chapter 17 The Assay of Thiamine in Food Henryk Zielinski and Juana Frias, 252, 
Chapter 18 Assays of Riboflavin in Food using Solid-phase Extraction Marcela A. Segundo, Marcelo V. Osório, Hugo M. Oliveira, Luísa Barreiros and Luís M. Magalhães, 271, 
Chapter 19 Isotope Dilution Mass Spectrometry for Niacin in Food Robert J. Goldschmidt and Wayne R. Wolf, 285, 
Chapter 20 Analysis of Pantothenic Acid (Vitamin B5) Tsutomu Fukuwatari and Katsumi Shibata, 302, 
Chapter 21 High-performance Liquid Chromatography Mass Spectrometry Analysis of Pantothenic Acid (Vitamin B5) in Multivitamin Dietary Supplements Pei Chen, 317, 
Chapter 22 Enzymatic HPLC Assay for all Six Vitamin B6 Forms Toshiharu Yagi, 335, 
Chapter 23 Analysis of Biotin (Vitamin B7) and Folic Acid (Vitamin B9): A Focus on Immunosensor Development with Liposomal Amplification Ja-an Annie Ho, Yu-Hsuan Lai, Li-Chen Wu, Shen-Huan Liang, Song-Ling Wong and Jr-Jiun Liou, 353, 
Chapter 24 Biotin Analysis in Dairy Products David C. Woollard and Harvey E. Indyk, 377, 
Chapter 25 Quantitation of Folates by Stable Isotope Dilution Assays Michael Rychlik, 396, 
Chapter 26 Analysis of Cobalamins (Vitamin B12) in Human Samples: An Overview of Methodology Dorte L. Lildballe and Ebba Nexo, 419, 
Chapter 27 Assay by Biosensor and Chemiluminescence for Vitamin B12 M.S. Thakur and L. Sagaya Selva Kumar, 439, 
Chapter 28 The Diagnostic Value of Measuring Holotranscobalamin (Active Vitamin B12) in Human Serum: A Clinical Biochemistry Viewpoint Fabrizia Bamonti and Cristina Novembrino, 458, 
Function and Effects, 
Chapter 29 B Vitamins (Folate, B6 and B12) in Relation to Stroke and its Cognitive Decline Concepción Sánchez-Moreno and Antonio Jiménez-Escrig, 481, 
Chapter 30 Epilepsy and B Vitamins Terje Apeland, Roald E. Strandjord and Mohammad Azam Mansoor, 504, 
Chapter 31 B Vitamins and Folate in Multiple Micronutrient Intervention: Function and Effects Faruk Ahmed, 524, 
Chapter 32 Wernicke's Encephalopathy caused by Thiamine (Vitamin B1) Deficiency Alan S. Hazell, 538, 
Chapter 33 Disturbances in Acetyl-CoA Metabolism: A Key Factor in Preclinical and Overt Thiamine Deficiency Encephalopathy Andrzej Szutowicz, Agnieszka Jankowska-Kulawy and Hanna Bielarczyk, 553, 
Chapter 34 Thiamine Deficiency and Neuronal Calcium Homeostasis Zunji Ke and Jia Luo, 572, 
Chapter 35 Role of Thiamine in Obesity-related Diabetes: Modification of the Gene Expression Yuka Kohda, Takao Tanaka and Hitoshi Matsumura, 580, 
Chapter 36 Riboflavin Uptake Magdalena Zielinska-Dawidziak, 592, 
Chapter 37 Riboflavin and β-oxidation Flavoenzymes Bárbara J. Henriques, João V. Rodrigues and Cláudio M. Gomes, 611, 
Chapter 38 Function and Effects of Niacin (Niacinamide, Vitamin B3) Ahmed A. Megan, Said O. Muhidin, Mahir A. Hamad and Mohamed H Ahmed, 633, 
Chapter 39 Pharmacological Use of Niacin for Lipoprotein Disorders John R. Guyton, Wanda C. Lakey, Kristen B. Campbell and Nicole G. Greyshock, 660, 
Chapter 40 Pellagra: Psychiatric Manifestations Ravi Prakash, Priyanka Rastogi and Suprakash Choudhary, 675, 
Chapter 41 Pantetheine and Pantetheinase: From Energy Metabolism to Immunity Takeaki Nitto, 685, 
Chapter 42 Function and Effects of Pyridoxine (Vitamin B6): An Epidemiological Review of Evidence Junko Ishihara and Hiroyasu Iso, 699, 
Chapter 43 Function and Effects of Biotin Jean-Jacques Houri, Philippe Mougenot, François Guyon and Bernard Do, 716, 
Chapter 44 The Importance of Folate in Health Abalo Chango, David Watkins and Latifa Abdennebi-Najar, 734, 
Chapter 45 Homocysteine and Vascular Disease: A Review of the Published Results of 11 Trials involving 52 260 Individuals Robert Clarke and Jane Armitage, 754, 
Chapter 46 Vitamin B12 and Folate in Dementia Rachna Agarwal, 769, 
Chapter 47 Cobalamin and Nutritional Implications in Kidney Disease Katsushi Koyama, 786, 
Subject Index, 805, 

CHAPTER 1

Historical Context of Vitamin B

HIDEYUKI HAYASHI

Department of Chemistry, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan Email: hayashi@art.osaka-med.ac.jp

1.1 Evidence for the Presence of Unidentified Factors Essential for Life

From ancient times, people were aware of the presence of a specific type of disease, beriberi, which affected people mainly in the East and South Asia. As early as 2600 BC, a Chinese account described that beriberi was caused by long-term rice eating but could be prevented by taking rice bran simultaneously. This finding was not recognized in modern medicine. However, in a similar context, the antiscorbutic effect of citrus fruits was already empirically known in the 17th century when James Lind of the Royal Navy systematically carried out experiments to demonstrate the beneficial effect of orange and lemon. Although he never thought that citrus juice is the only solution to scurvy, the surgeons of the Royal Navy were...

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 1849733694
• ISBN 13: 9781849733694
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 855
• Herausgeber: Preedy Victor R.
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: preigu; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; 49078; Deutschland