NanoFormulation (Special Publications) - Hardcover

Hardcover

ISBN 10: 1849733783 ISBN 13: 9781849733786

Verlag: Royal Society of Chemistry, 2012

Inhaltsangabe

This book is as a result of the conference NanoFormulation 2011 held in Singapore as part of the ICMAT group of symposia. It covers advances in research, development and applications of innovative formulation technologies where nanomaterials play an essential role. With contributions from leading researchers and practitioners worldwide, the book is essential reading for scientists interested in the area of the nanoscale in formulations. Topics covered in the book include formulation of nano-biomaterials, handling and processing of nanopowders, processing and stabilisation of nanoparticle suspensions, physical chemistry at the nanoscale, smart and functional materials in formulations eg coatings, films and tapes and safety and health effects of nanoscale materials.

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This book is as a result of the conference NanoFormulation 2011 held in Singapore as part of the ICMAT group of symposia. It covers advances in research, development and applications of innovative formulation technologies where nanomaterials play an essential role. With contributions from leading researchers and practitioners worldwide, the book is essential reading for scientists interested in the area of nanoscale in formulations. Topics covered in the book include formulation of nano-biomaterials, handling and processing of nanopowders, processing and stabilisation of nanoparticle suspensions, physical chemistry at the nanoscale, smart and functional materials in formulations eg coatings, films and tapes and safety and health effects of nanoscale materials.

Auszug. © Genehmigter Nachdruck. Alle Rechte vorbehalten.

NanoFormulation

By Gordon J.T. Tiddy, Reginald B.H. Tan

The Royal Society of Chemistry

Copyright © 2012 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-84973-378-6

Contents

Formulation of Nano-Bio Materials, 
Formulating Nanoparticles To Achieve Oral And Intravenous Delivery Of Challenging Drugs (Keynote Lecture) Christine Vauthier, 3, 
The Preparation, Optimization And Characterization Of Viral Protein Complexed Liposomes (Oral) Shailja Tiwari, Sunil K. Verma and Suresh P. Vyas, 20, 
Development And In Vitro Evaluations Of A Lipid Nanoparticle Formulation Containing Tretinoin Surajit Das, Wai Kiang Ng and Reginald B.H. Tan, 38, 
The Phase Behaviour Of Saturated And Unsaturated Monoglycerides And The Influence Of Triglyceride On The Aggregation In A Hydrophobic System Abdullatif Alfutimie, Robin Curtis, and Gordon J. T. Tiddy, 53, 
Tamoxifen Loaded Auto-Assembled Nanoparticles For Oral Delivery: Cytotoxicity And Permeability Studies S. Barbieri, F. Sonvico, K. Bouchemal, G. Ponchel and P. Colombo, 70, 
Formulation Of Gliclazide Encapsulated Chitosan Nanoparticles: In Vitro And In Vivo Evaluation Ranjith Kumar Averineni, Gopal Venkatesh Shavi, Om Prakash Ranjan, Praful Balavant Deshpande, Gurram Aravind Kumar, Usha Yogendra Nayak, Meka Sreenivasa Reddy and Nayanabhirama Udupa, 77, 
Handling And Processing Of Nanopowders, 
Nanocomposites Prepared By Ultrasonic Spray Pyrolysis And Their Applications (Oral) Rongbo Zheng, 89, 
Sintering Studies On The Various Properties Of Barium Titanate Nanoparticles Synthesized By A Novel Technique T. Sundararajan, T. Karthi and, S. Balasivanandha Prabu, 94, 
Dry Powder Nanoparticulate Formulations For Mucosal Vaccination Regina Scherließ and Simon Buske, 104, 
Functionalization Of SiO2 Nanoparticles And Their Superhydrophobic Surface Coating Y. H. Sehlleier, A. Abdali, T. Hulser, H. Wiggers and C. Schulz, 113, 
Influence Of The Structural Characteristics Of Silver And Gold Nanoparticles On The Surface-Enhancement Factors Of The Raman Signals From Aromatic Amines Katrina A. Smith, Ngee Sing Chong, Kiran Donthula, and Beng Guat Ooi, 121, 
Processing And Stabilisation Of Nanoparticle Suspensions, 
Microfluidics Reaction Technology (MRT) For Continuous Production For Nano-Formulations Of Drug Entities And Advanced Materials (Oral) T. Panagiotou, K.J. Chomistek and R.J. Fisher, 135, 
Formulation And Evaluation Of Solid Lipid Nanoparticulate Gel For Antiacne Therapy Ajay Kumar, Neha Gulati, Randhir Gupta, Koshy MK and Shubhini A. Saraf, 150, 
The Effect Of Formulation And Process Variables On Droplet Size Reduction Using A High-Throughput Processing Platform Vicky Riding, Daniel Harvey, Peter J. Martin and Adam J. Kowalski, 160, 
Physical Chemistry At The Nanoscale, 
Nanoparticles In Organic Solvents With Polymers – Stability And Consequences Upon Material Synthesis Through Spray Drying And Melt Moulding (Oral) M. Rudolph, C. Turan, S. Kirchberg, G. Ziegmann and U.A. Peuker, 177, 
Thermal Investigation Of Copper-Doped-Zirconia Nanoparticles L. Mikac, M. Ivanda, G. Stefanie, S. Music, K. Furic and D. Car, 188, 
Morphological Studies Of Polyaniline/TiO2 Polymer Composite N. Narsimlu, B. Kavitha, D. Srinivasu and K. Sivakumar, 194, 
Bound Water Investigations On Disaccharide Based Glycolipids Seyed Mohammad, Mirzadeh Hosseini, Rauzah Hashim, Thorsten Heidelberg and Bakir A. Timimi, 205, 
Smart And Functional Materials In Formulations: Coatings, Films And Tapes, 
Highly-Branched Poly(N-Isopropyl Acrylamide (Keynote) Stephen Rimmer, 215, 
Saxs Studies Of Poly (3-Octylthiophene) And Poly (3,3"-Dioctyl-2,2",5'2" Terithiophene) Polymer Thin Films K. Sivakumar, B. Kavitha, C. Wu and N. Narsimlu, 235, 
Safety And Health Effects Of Nanoscale Materials: Towards Sustainable And Safe Nanomaterials, 
Short-Term Exposure To Nanoparticle-Rich Diesel Engine Exhaust Causes Changes In Brain Activity But Not In Cognitive Performance In Human Volunteers (Keynote), 
Anique Driessen, Bjorn Crilts, Ludo van Etten, Anica Crilts, Paul Fokkens, Flemming Cassee and Paul J.A. Borm, 243, 
Nano-Sized Delivery For Agricultural Chemicals Min Zhao, Lei Liu, Robert Ehr, Tom Kalantar, Dale Schmidt, Todd Mathieson, Mike Tolley, Kerrm Yau, Steven Wensing, Qiang Zhan, Mark Zettler, Ze-Sheng Li and Dan Zweifel, 256, 
Subject Index, 266, 

CHAPTER 1

FORMULATING NANOPARTICLES TO ACHIEVE ORAL AND INTRAVENOUS DELIVERY OF CHALLENGING DRUGS

Christine Vauthier

1 INTRODUCTION

Existing treatments of severe diseases like cancer, severe infections and metabolic disease are limited by the general toxicity or by the low bioavailability of drugs or by both of these limitations. It has been found that associating such drugs with a carrier of colloidal size ranging from around 10 nm to several hundred nanometers was a relevant clinical approach to develop new effective and safe therapies. The benefit comes from the fact that carriers can modify the in vivo fate of the drug by changing its biodistribution. In this aim, the carrier is expected to modulate the different phases controlling drug bioavailability and biodistribution in the way it will improve the delivery to the target tissues and cells. The different processes that can be affected include absorption, distribution, metabolism and elimination when the drug is administered by the oral route or by an extravascular route. After intravenous administration, processes that need to be modulated include the distribution, the metabolism and the elimination of the drug.

The fact that carriers of colloidal size can be used to change absorption, metabolism and elimination of drugs also gives opportunity for challenging molecules to be developed. Those include new antiviral and anticancer drugs. For instance, several are small drug molecules with a low solubility in aqueous media. Others are molecules highly metabolized in biological medium. Finally, they can be part of the new generation of molecules with a very specific biological activity but unstable in biological media and incapable to cross biological barriers. A typical example of challenging small molecule is paclitaxel. It is a powerful anticancer agent widely used in clinics. However, it is a substrate of cytochrome P-450 (i.e. CYP3A4) and of the efflux pump Pgp hampering its delivery by the oral route. Those two effects greatly hamper the oral absorption of paclitaxel making this drug only administrable by parenteral routes. In addition, because this drug is a substrate of the Pgp efflux pump, treatments are rapidly inefficient due to the occurrence of a resistance to the treatment. Other molecules include peptides, proteins and nucleic acids. All these compounds are highly metabolized whatever the route of administration. They also hardly diffuse across biological barriers because of their high molecular weight and their hydrophilic characteristics.

In general, stability of drugs in biological media is well improved after association with a carrier whatever the drugs and the route of administration. Thus the most challenging goals are to improve absorption of poorly absorbed molecules by the oral route and to perfectly control the biodistribution of drugs after intravenous administration. It appears from many works that a key for the success of the approach is closely related to the adequate formulation of the carrier including a small size and suitable surface properties. The small size is mandatory to allow the drug carrier to diffuse in tissues. Regarding surface of...

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 1849733783
• ISBN 13: 9781849733786
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 282
• Herausgeber: Tiddy Gordon, Tan Reginald
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: GPSR Kontakt; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Deutschland