Reducing, Refining and Replacing the Use of Animals in Toxicity Testing (Issues in Toxicology, Band 19) - Hardcover

Hardcover

ISBN 10: 1849736529 ISBN 13: 9781849736527

Verlag: Royal Society of Chemistry, 2013

Inhaltsangabe

1. Describes the alternative methods to using animals for toxicity testing.

2. It is important to reduce, where possible, the use of animals in laboratory research.

3. Toxicologists, medicinal chemists, health and saftey officers.

4. Toxicology Resarch, RSC Drug Discovery Series

5. This text will explore the complexities associated with adequate validation, and the assessment of different test methods' reliability and relevance.

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods.

This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. Many methods currently involve laboratory animals. Alternative procedures are now being developed which reduce, refine, or replace animal usage. Aimed at postgraduates, academics and industrialists, this book describes the ever-expanding "toolbox" of methods now available. These often result from our growing understanding of the biochemical pathways that mediate toxicity. By combining various techniques to build a "weight of evidence", toxicologists are developing mechanistically based alternatives to experimentation on live animals. This text also emphasizes the importance of adequate test validation, reliability and relevance.

Über diesen Titel

Über die Autorin bzw. den Autor

David G. Allen has over 10 years experience in molecular and cellular biology. This includes the evaluation of toxicological and pharmacological data for the Food and Drug Administration (FDA), and the identification and validation of alternative toxicological assays that reduce or replace animal usage in regulatory safety testing. He received is BSc and PhD from North Carolina State University in Raleigh, and his MSc from the University of North Carolina in Wilmington. Dr Allen is currently Director of the Environmental and Regulatory Sciences Division of Integrated Laboratory Systems in North Carolina. This involves responsibility for the evaluation of alternative toxicological methods and comprehensive environmental services for the Environmental Protection Agency and the State of Georgia. The role includes all aspects of divisional management such as staffing, budget projections, and business development.

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Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods.

This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Aus dem Klappentext

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods.

This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2013
• Sprache: Englisch
• ISBN 10: 1849736529
• ISBN 13: 9781849736527
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 369
• Herausgeber: Allen David G., Waters Michael D.
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar