In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced. The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency. This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
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Xuhong Qian is a professor of bioorganic chemistry and engineering, and President of the East China University of Science and Technology. He has previously acted as president for the Asian Pacific Confederation of Chemical Engineering (APCChE), and is currently a member of the Advisory Commission for Chemistry, the National Natural Science Foundation of China and the Chinese Academy of Engineering. He is a Fellow of The Royal Society of Chemistry and an Ambassador Scientist of the Alexander von Humboldt Foundation.
Zhenjiang Zhao has been an Associate Professor at the East China University of Science and Technology since 2010. His research interests focus on medicinal chemistry, enzyme inhibitors and agrochemicals.
Yufang Xu is a Professor at the East China University of Science and Technology. She received her PhD in Chemistry from the East China University of Science and Technology in 1994 and from 1999 to 2001 she worked as a postdoctoral fellow at the Tokyo Medical and Dental University in Japan. Her research interests focus on small organic molecules to regulate the bioprocess.
Jianhe Xu is the Professor and Director of the State Key Laboratory of Bioreactor Engineering at East China University of Science and Technology and is the Cheungkong Professor of the Chinese Ministry of Education. He graduated from Tsinghua University in 1987, finished his PhD from East China University of Science and Technology and Kyoto University in 1995.
In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced.
The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency.
This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced.
The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency.
This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
Chapter 1 From Chemical Biology to Its Technology and Engineering Xuhong Qian, Zhenjiang Zhao, Jian-He Xu, Yufang Xu, Yi-Heng Percival Zhang, Fengxian Hu, Jingyan Zhang, and Yang-Chun Yong,
Chapter 2 Chemical Modulators for Enzymatic Reactions,
Chapter 3 Regulation of Non-canonical DNA Structures by Small Molecules and Carbon Materials Chong Wang, Jingyan Zhang, and Shouwu Guo,
Chapter 4 Chemical Biotechnology of In Vitro Synthetic Biosystems for Biomanufacturing Zhiguang Zhu and Yi-Heng Percival Zhang,
Chapter 5 Chemical Bioengineering in Microbial Electrochemical Systems Dan-Dan Zhai and Yang-Chun Yong,
Chapter 6 Chemical Bioengineering in Plant Cell Culture Fengxian Hu, Yufang Xu, and Zhenjiang Zhao,
Chapter 7 Chemical Biotechnology for Plant Protection Zhenjiang Zhao, Yufang Xu, and Xuhong Qian,
Subject Index,
From Chemical Biology to Its Technology and Engineering
XUHONG QIAN, ZHENJIANG ZHAO, JIAN-HE XU, YUFANG XU, YI-HENG PERCIVAL ZHANG, FENGXIAN HU, JINGYAN ZHANG, AND YANG-CHUN YONG
Shanghai Key Laboratory of Chemical Biology and State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Cell Free Bioinnovations Inc., 2200 Kraft Drive, Suite 1200B, Blacksburg, VA 24060, USA; School of Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Biofuels Institute, School of the Environment, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China
E-mail: xhqian@ecust.edu.cn
1.1 The History and Applications of Biotechnology
The term 'biotechnology' first appeared in Manchester University, England, early in the 20th century. In 1912, C. Weizmann isolated a strain of Clostridium acetobutylicum that converted carbohydrate into butanol, acetone, and ethanol. In 1923, T. Walker commenced undergraduate education in the department of fermentation industries; the name of this department was then changed to industrial biochemistry, similar to 'biotechnology'. K. Ereky, a Hungarian engineer and the founding father of biotechnology, first coined the word "biotechnology" in a book published in Berlin in 1919 called Biotechnologie der Fleisch-, Fett- und Milcherzeugung im landwirtschaftlichen Grossbetriebe (Biotechnology of Meat, Fat and Milk Production in an Agricultural Large-Scale Farm), in which he explained a bioprocess technology that converts raw materials into a more valuable product. He further developed this concept for the 20th century: Biotechnology means solutions to many social and natural crises, such as food and energy shortages.
In fact, biotechnology as a methodology has existed for a long time, although the term "biotechnology" did not exist then. Around 8000 BC yeast was used to make wheat wine by the Chinese, and also around 6000 BC by the Sumerians and Babylonian
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