Glycopolymer Code: Synthesis of Glycopolymers and Their Applications (Rsc Polymer Chemistry, 15, Band 15) - Hardcover

Hardcover

ISBN 10: 1849739781 ISBN 13: 9781849739788

Verlag: Royal Society of Chemistry, 2015

Inhaltsangabe

Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. Glycopolymer Code discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research.

Specific chapters cover both basic and advanced synthesis techniques to prepare glycopolymers, the analytical techniques used to investigate lectin receptor glycopolymer interactions, the properties and types of lectins that are widely used to understand the multivalent interactions and various applications of synthetic glycopolymers.

With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.

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Über die Autorin bzw. den Autor

Dr. Becer is currently a senior lecturer in Materials Science at Queen Mary, University of London. He has been working on developing new polymer synthesis techniques and functional materials such as smart polymers, glycopolymers. The latter has been in the focus of Dr. Becer’s research in the last five years and he has been published several research and review articles on this topic. Dr. Becer has several collaboration partners working on glycopolymers and has good links with other academics working on this field all around the World.

Dr. Hartmann is currently working as an independent Emmy Noether research groupleader at the MPI of Colloids and Interfaces in the Department of Biomolecular Systems (head: Prof. Peter H. Seeberger). Her research interests focus on the synthesis of biomimetic macromolecules and hydrogels combining synthetic scaffolds based on monodisperse, sequence-defined oligo/polymers with biological ligands such as sugars or peptides. She has published a number of papers related to her work on carbohydrate functionalized polymers and has several collaboration partners working in the area of carbohydrate and material research as well as good links with other academics working in this field around the World.

Von der hinteren Coverseite

Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. Glycopolymer Code discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research.

Specific chapters cover both basic and advanced synthesis techniques to prepare glycopolymers, the analytical techniques used to investigate lectin receptor glycopolymer interactions, the properties and types of lectins that are widely used to understand the multivalent interactions and various applications of synthetic glycopolymers.

With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.

Aus dem Klappentext

Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. Glycopolymer Code discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research.

Specific chapters cover both basic and advanced synthesis techniques to prepare glycopolymers, the analytical techniques used to investigate lectin receptor glycopolymer interactions, the properties and types of lectins that are widely used to understand the multivalent interactions and various applications of synthetic glycopolymers.

With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.

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Glycopolymer Code

Synthesis of Glycopolymers and Their Applications

By C. Remzi Becer, Laura Hartmann

The Royal Society of Chemistry

Copyright © 2015 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-84973-978-8

Contents

Chapter 1 Small Molecule Ligands for Bacterial Lectins: Letters of an Antiadhesive Glycopolymer Code Thisbe K. Lindhorst, 
Chapter 2 Direct Synthesis of Glycopolymers Using Glycomonomers S. R. Simon Ting and Martina H. Stenzel, 
Chapter 3 Synthesis and Characterization of Glycopolypeptides Kai-Steffen Krannig and Helmut Schlaad, 
Chapter 4 Multivalent Glycocalixarenes: Synthesis and Molecular Recognition Alessandro Dondoni and Alberto Marra, 
Chapter 5 Dendritic Glyco Architectures – From H-Bond-Driven Molecular Interactions to Their Potential Use in Brain Disease Therapy Dietmar Appelhans, Josep Cladera, Mark Rogers, and Brigitte Voit, 
Chapter 6 Self-Assembly of Glycopolymers: From Nano-Objects to Hydrogels Yu Zhao, Gaojian Chen, and Guosong Chen, 
Chapter 7 Glyconanoparticles: Synthesis and Biomedical Applications Yinan Wang, Stephen Quan, Piyush Kumar, and Ravin Narain, 
Chapter 8 Hybrid Glycopolymer Materials and Their Expansive Applications Marta Fernández-García and Alexandra Muñoz-Bonilla, 
Chapter 9 Glycopolymers in Biosensing Applications Yoshiko Miura and Hirokazu Seto, 
Subject Index, 

CHAPTER 1

Small Molecule Ligands for Bacterial Lectins: Letters of an Antiadhesive Glycopolymer Code

THISBE K. LINDHORST

1.1 Introduction

This chapter discusses how glycopolymers might function in the context of microbial adhesion. This is an important topic as attachment of viruses and bacteria to surfaces is a global problem and for host organisms it has fundamental implications for their vitality. This was considered when the human microbiome project was launched in 2008. Consequently, the human microbiome project is dedicated to research into how changes of microbial colonization influence human health and disease.

It has turned out that microbial colonization of the body is largely associated with the glycoconjugate decoration of the host cells, named the 'glycocalyx.' The glycocalyx of a cell is an extracellular compartment comprising a huge variety of different glycoconjugates. Strikingly, it forms an anchoring platform for invading microbes. It has been asked how carbohydrate recognition has evolved among microbes, how it is regulated and how it develops during the lifetime of an organism, in other words, how binding to cell surface carbohydrates is being 'spelled' (Figure 1.1). It has been suggested that the oligo- and polysaccharide structures that are expressed on cell surfaces function in the sense of a 'glycocode,' thus paralleling the biology of carbohydrates with the alphabet of a language, in order to decipher its meaning. Of course, it is sensible to consider the diversity of carbohydrate structures as a biologically meaningful concert corresponding to the whole of molecular interactions. Glycopolymers can be regarded as a means to interrogate a putative carbohydrate alphabet and, moreover, as a powerful tool to prevent microbial colonization of surfaces.

1.2 Lectin-Mediated Bacterial Adhesion

To colonize cell surfaces of the host, bacteria, for example, have to accomplish a process of adhesion in order to withstand natural defence mechanisms and mechanical shear stress. Stable adhesion can lead to the formation of bacterial biofilms, which is accompanied by vital advantages for the microbial colonies but

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2015
• Sprache: Englisch
• ISBN 10: 1849739781
• ISBN 13: 9781849739788
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 280
• Herausgeber: Becer C. Remzi, Hartmann Laura
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: preigu; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; 49078; Deutschland