Data Mining in Bioinformatics (Advanced Information and Knowledge Processing) - Hardcover

Buch 8 von 66: Advanced Information and Knowledge Processing
 
9781852336714: Data Mining in Bioinformatics (Advanced Information and Knowledge Processing)
Hardcover
ISBN 10: 1852336714 ISBN 13: 9781852336714
Verlag: Springer, 2004

Inhaltsangabe

8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues,its3Dstructureandactivesites,itsfunctionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support. The context of protein functionality is well represented by protein subcellular location. Proteins have various subcellular location patterns [250]. One major category of proteins is synthesized on free ribosomes in the cytoplasm. Soluble proteins remain in the cytoplasm after their synthesis and function as small factories catalyzing cellular metabolites. Other proteins that have a target signal in their sequences are directed to their target organelle (such as mitochondria) via posttranslational transport through the organelle membrane. Nuclear proteins are transferred through pores on the nuclear envelope to the nucleus and mostly function as regulators. The second major category of proteins is synthesized on endoplasmic reticulum(ER)-associated ribosomes and passes through the reticuloendothelial system, consisting of the ERand the Golgi apparatus.

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Verlag
Springer
Erscheinungsdatum
2004
Sprache
Englisch
ISBN 10 
1852336714
ISBN 13 
9781852336714
Einband
Gebundene Ausgabe
Anzahl der Seiten
352
Herausgeber
Wang Jason T. L., Zaki Mohammed J., Toivonen Hannu, Shasha Dennis
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