Protein–protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis: Functional role of ... and drug resistance in M. tuberculosis - Softcover

Bhargavi, Gunapati; Hassan, Sameer; Balaji, Subramaniam; Palaniyandi, Kannan

 
9781952751981: Protein–protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis: Functional role of ... and drug resistance in M. tuberculosis
Softcover
ISBN 10: 1952751985 ISBN 13: 9781952751981
Verlag: Eliva Press, 2020

Inhaltsangabe

Mycobacterium tuberculosis resides inside host macrophages during infection and adapts to resilient stresses generated by the host immune system. As a response, M. tuberculosis codes for short-chain dehydrogenases/ reductases (SDRs). These SDRs are nicotinamide adenine dinucleotide-reliant oxidoreductases involved in cell homeostasis. The precise function of oxidoreductases in bacteria especially M. tuberculosis were not fully explored. In this study, for the first time, we attempted to predict the functional role of one of the hypothetical oxidoreductase Rv0148 of M. tuberculosis. Overall, the study suggested that Rv0148, though a non-essential gene, is functionally involved in drug resistance and is interconnected with other drug-resistance genes. The absence of Rv0148 displays its prominent role in host immunity.

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Verlag
Eliva Press
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
1952751985
ISBN 13 
9781952751981
Einband
Taschenbuch
Anzahl der Seiten
38
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