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Structure and Function of GPCRs (Topics in Medicinal Chemistry, 30, Band 30) - Hardcover

Buch 29 von 38: Topics in Medicinal Chemistry
 
9783030245894: Structure and Function of GPCRs (Topics in Medicinal Chemistry, 30, Band 30)
Hardcover
ISBN 10: 3030245896 ISBN 13: 9783030245894
Verlag: Springer, 2019

Inhaltsangabe

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. 

Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.

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Von der hinteren Coverseite

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. 

Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.

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Verlag
Springer
Erscheinungsdatum
2019
Sprache
Englisch
ISBN 10 
3030245896
ISBN 13 
9783030245894
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
303
Herausgeber
Lebon Guillaume
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