Regulation of Chemokine-Receptor Interactions and Functions - Softcover

Softcover

ISBN 10: 3038427284 ISBN 13: 9783038427285

Verlag: MDPI, 2018

Inhaltsangabe

A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated.

Über diesen Titel

Über die Autorin bzw. den Autor

Monash University Australia

Details zur Ausgabe

• Verlag: MDPI
• Erscheinungsdatum: 2018
• Sprache: Englisch
• ISBN 10: 3038427284
• ISBN 13: 9783038427285
• Einband: Taschenbuch
• Auflage: 1
• Anzahl der Seiten: 228
• Herausgeber: Stone Martin J.
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar