Ribosome Inactivating Toxins - Softcover

Softcover

ISBN 10: 3038972487 ISBN 13: 9783038972488

Verlag: MDPI, 2019

Inhaltsangabe

Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs.

Über diesen Titel

Über die Autorin bzw. den Autor

SIMOPRO, JOLIOT, CEA, Université Paris-Saclay, F-91191 Gif Sur Yvette, France

Details zur Ausgabe

• Verlag: MDPI
• Erscheinungsdatum: 2019
• Sprache: Englisch
• ISBN 10: 3038972487
• ISBN 13: 9783038972488
• Einband: Taschenbuch
• Auflage: 1
• Anzahl der Seiten: 329
• Herausgeber: Barbier Julien, Gillet Daniel
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: preigu; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; 49078; Deutschland