Chromosomal Instability in Cancer Cells: 200 (Recent Results in Cancer Research) - Hardcover

Hardcover

ISBN 10: 3319202901 ISBN 13: 9783319202907

Verlag: Springer, 2015

Inhaltsangabe

<P>THIS ISSUE OF <I>RECENT RESULTS IN CANCER RESEARCH</I> PRESENTS A COMPREHENSIVE REVIEW OF CURRENT UNDERSTANDING OF CHROMOSOMAL INSTABILITY IN CANCER AND OF STRATEGIES TO USE THIS INFORMATION FOR BETTER TREATMENT OF PATIENTS WITH CANCER. CANCER IS A DISEASE OF THE CHROMOSOMES, AND CHROMOSOMAL INSTABILITY IN CANCER DISRUPTS GENE FUNCTION BY EITHER INACTIVATING TUMOR SUPPRESSOR GENES OR ACTIVATING GROWTH-PROMOTING ONCOGENES. THE CHROMOSOMAL BASIS FOR THESE ABERRATIONS IS EITHER TRANSLOCATIONS, WHICH CHANGE THE INTEGRITY OF GENES, OR ABNORMAL NUMBERS OF CHROMOSOMES, A CONDITION REFERRED TO AS ANEUPLOIDY, WHICH RESULTS IN ABNORMAL GENE EXPRESSION LEVELS. SUCH STRUCTURAL OR NUMERICAL CHROMOSOMAL ABERRATIONS ARE SPECIFIC FOR DISTINCT TUMOR ENTITIES. THE DEGREE OF CHROMOSOMAL INSTABILITY AND THE DEGREE OF INTRATUMOR HETEROGENEITY HAVE PROFOUND CONSEQUENCES FOR DISEASE OUTCOME AND FOR THERAPEUTIC STRATIFICATION.</P>

Über diesen Titel

Reseña del editor:

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Über diese Auflage

• Verlag: Springer
• Erscheinungsdatum: 2015
• ISBN 10: 3319202901
• ISBN 13: 9783319202907
• Einband: Tapa dura
• Auflage: 1
• Anzahl der Seiten: 234
• Herausgeber: Ghadimi B. Michael, Ried Thomas