Chromatin Regulation of Early Embryonic Lineage Specification (Advances in Anatomy, Embryology and Cell Biology, Band 229) - Softcover

Softcover

ISBN 10: 3319631861 ISBN 13: 9783319631868

Verlag: Springer, 2017

Inhaltsangabe

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. 

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Über die Autorin bzw. den Autor

Dr. Jason Knott is a reproductive and developmental biologist with fifteen years of experience in mammalian embryology and stem cell biology. His research program is focused on elucidating chromatin based mechanisms that regulate gene expression programs and cell-fate determination in preimplantation embryos and embryonic stem cells. His current research focus is on understanding transcriptional and epigenetic mechanisms that govern cell polarity, pluripotency, trophoblast lineage formation, and trophoblast lineage differentiation in mice, humans, and cattle. 

Dr. Keith Latham is a developmental biologist with nearly three decades of experience in mammalian embryology.  His research encompasses epigenetics and imprinting in the early embryo, transcriptional control, translational control, determinants of oocyte quality, and mechanisms underlying meiotic spindle formation and function.  His research combines the use of diver

se mouse strains, molecular assays applicable to the single cell level, and embryo micromanipulation including different forms of nuclear transfer.

Von der hinteren Coverseite

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

Details zur Ausgabe

• Verlag: Springer
• Erscheinungsdatum: 2017
• Sprache: Englisch
• ISBN 10: 3319631861
• ISBN 13: 9783319631868
• Einband: Taschenbuch
• Auflage: 1
• Anzahl der Seiten: 88
• Herausgeber: Knott Jason, Latham Keith
• Kontakt zum Hersteller: GPSR Kontakt; ProductSafety@springernature.com; ; Slevogtstraße 3-5; Heidelberg; 69126; Deutschland