Quasispecies: From Theory to Experimental Systems (Current Topics in Microbiology and Immunology, Band 392) - Softcover

Softcover

ISBN 10: 3319795481 ISBN 13: 9783319795485

Verlag: Springer, 2018

Inhaltsangabe

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

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Über die Autorin bzw. den Autor

Esteban Domingo is a professor at the Spanish Research Council at Centro de Biología Molecular Severo Ochoa (Madrid) and President of the Spanish Society of Virology. He is a member of EMBO and Real Academía de Ciencias Exactas, Físicas y Naturales. Peter Schuster, em. professor of University of Vienna is a member of Leopoldina, Nationale Akademie der Wissenschaften, National Academy of Sciences USA, European Academy of Sciences and Arts and several other institutions. He worked together with Manfred Eigen and developed together with him the concepts of "quasispecies" and "hypercycles".

Details zur Ausgabe

• Verlag: Springer
• Erscheinungsdatum: 2018
• Sprache: Englisch
• ISBN 10: 3319795481
• ISBN 13: 9783319795485
• Einband: Taschenbuch
• Anzahl der Seiten: 372
• Herausgeber: Domingo Esteban, Schuster Peter
• Kontakt zum Hersteller: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Deutschland