MIF Family Cytokines in Innate Immunity and Homeostasis (Progress in Inflammation Research) - Softcover

Buch 45 von 50: Progress in Inflammation Research
 
9783319848822: MIF Family Cytokines in Innate Immunity and Homeostasis (Progress in Inflammation Research)
Softcover
ISBN 10: 3319848828 ISBN 13: 9783319848822
Verlag: Springer, 2018

Inhaltsangabe

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses.  MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized.  MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

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Über die Autorin bzw. den Autor

Richard Bucala, MD PhD; Professor of Medicine, Pathology, and Epidemiology & Public Health at Yale University, School of Medicine, New Haven, CT, USA Jürgen Bernhagen, PhD; Institute of Biochemistry and Molecular Cell Biology, Universitätsklinikum Aachen, RWTH Aachen, Germany

Von der hinteren Coverseite

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses.  MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized.  MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

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Verlag
Springer
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
3319848828
ISBN 13 
9783319848822
Einband
Taschenbuch
Anzahl der Seiten
256
Herausgeber
Bucala Richard, Bernhagen Jürgen
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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Vorgestellte Ausgabe

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Verlag: Springer, 2017
Hardcover