Method Development and Validation for Voriconazole Estimation: RP-HPLC and UV Spectrophotometric Methods in Bulk and Pharmaceutical Formulations - Softcover

Srinivasa Rao, Yarguntla; Vara Prasada Rao, K.

Softcover

ISBN 10: 3330051337 ISBN 13: 9783330051331

Verlag: LAP LAMBERT Academic Publishing, 2024

Inhaltsangabe

A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 × 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the λmax determined to be 223 nm. The method exhibited linearity over a concentration range of 5–30 µg/mL. Validation parameters, including linearity, range, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ), were assessed and met the required standards.

Über diesen Titel

Über die Autorin bzw. den Autor

The author earned his B.Pharmacy, M.Pharm, and Ph.D. from Andhra University. His postdoctoral research at Kyoto Pharmaceutical University, Japan, focused on designing and evaluating microneedle drug delivery systems for controlled release. He received the "Young Scientist Award-2016" from CEGR, New Delhi, and won four Best Research Paper Awards.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2024
• Sprache: Englisch
• ISBN 10: 3330051337
• ISBN 13: 9783330051331
• Einband: Taschenbuch
• Anzahl der Seiten: 80
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Editions universitaires europeennes; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland