Extraction and Crystal Structure of Physalin B - Softcover

Yang, Yan-jun

 
9783330082236: Extraction and Crystal Structure of Physalin B
Softcover
ISBN 10: 3330082232 ISBN 13: 9783330082236
Verlag: LAP LAMBERT Academic Publishing, 2017

Inhaltsangabe

Physalin B (C28H32O9), a main active physalin of Physalis angulata L was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P2(1) with C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)Å, V = 2607.97(5)Å3, Z = 4,Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, and μ= 0.870 mm-1. The final R = 0.0389 and wR = 0.1037 for 47670 observed reflections (I > 2ο(I)). The rigid molecule consists of eight fused rings involving two lactones.. There are two C28H32O9 molecules in an symmetric unit, and the title compound is stacked into a 3D layer structure through hydrogen bonds.In the 5-20μmol/L range, physalin B can significantly inhibit the secretion of inflammatory cytokines TNF-α and IL-6 on RAW264.7 cells. The results suggest that physalin B has anti-inflammatory activity in vitro.

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Über die Autorin bzw. den Autor

Yang Yanjun¿professor of pharmacy, involved in natural active drug research about more than 25 years, mainly ficused on high-active drug structures and new structure types, has discovered 4 new compounds, got 5 invention patents and published more than 40 research papers.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2017
Sprache
Englisch
ISBN 10 
3330082232
ISBN 13 
9783330082236
Einband
Taschenbuch
Anzahl der Seiten
60
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

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Riga
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