Mechanistic Approach Towards Discovery of Catalytic Acylation Reaction - Softcover

Zhang, Wanying

Softcover

ISBN 10: 3330327367 ISBN 13: 9783330327368

Verlag: LAP LAMBERT Academic Publishing, 2017

Inhaltsangabe

The development of new, efficient methods for the formation of carbon-carbon bonds using transition metal catalysis has broad applications in the field of organic chemistry and is the key to efficient chemical synthesis. Many efforts had been made to develop efficient ways to make these linkages particularly with the aid of metals such as Rh, Pd, Ni, Ru and Cu. Chapter 1 describes attempts that were conducted to achieve hydroacylation between an aldehyde and a non-conjugated alkene via a metal hydride intermediate. The use of RuHCl(CO)(PPh3)3 proved to be the most efficient catalyst for this transformation thus far. Mechanistic investigations were conducted to explore different possibilities to enable this transformation. This chapter also identifies a new self-aldol domino reaction, which consists of a self-aldol condensation of an aldehyde, followed by oxidation and decarbonylation giving rise to a ketone product. Chapter 2 describes a novel Suzuki-Miyaura system that couples esters and boronic esters to form the corresponding ketone product. It was found that an NHC-based Pd catalyst is crucial in the transformation wherein it activates the C(acyl)-O bond of the ester.

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Über die Autorin bzw. den Autor

Wanying Zhang finished her undergraduate degree at McGill University with an Honours in Chemistry and Minor in French Language and Literature. She continued to pursue her masters degree at University of Ottawa with a focus on Organometallic Chemistry and Green Chemistry, which culminated to this thesis and a publication in JACS.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2017
• Sprache: Englisch
• ISBN 10: 3330327367
• ISBN 13: 9783330327368
• Einband: Tapa blanda
• Anzahl der Seiten: 224
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar