Silicon-mediated Transformations of Functional Groups - Hardcover

Vorbrueggen, Helmut

Hardcover

ISBN 10: 3527306684 ISBN 13: 9783527306688

Verlag: Blackwell Verlag GmbH, 2004

Inhaltsangabe

IN THE FIRST WORK TO COMPREHENSIVELY COVER THIS ALL–IMPORTANT TOPIC, THE RECOGNIZED EXPERT HELMUT VORBRÜGGEN PROVIDES BOTH ORGANIC AND BIOORGANIC CHEMISTS WITH MUCH NEW AND VALUABLE INFORMATION FOR PREPARATIVE SYNTHESIS. ALTHOUGH EVERY ORGANIC CHEMIST MAY BE FAMILIAR WITH DIFFERENT ASPECTS OF SILYLATION FOR THE PROTECTION OF FUNCTIONAL GROUPS, THIS BOOK COVERS THE CONCEPT OF PROTECTION WHILE SIMULTANEOUSLY SILYLATING–ACTIVATING VARIOUS FUNCTIONAL GROUPS, SUCH AS AMIDES AND UREAS. THIS NOVEL METHODOLOGY OPENS THUS NUMEROUS SYNTHETIC PATHWAYS WHILE EFFECTING THE ELIMINATION OF WATER IN IT VOLATILE PERSILYLATED FORM UNDER RATHER MILD REACTION CONDITIONS, WHICH ARE OFTEN ADVANTAGEOUS COMPARED TO CONVENTIONAL METHODS. THE COMPACT FORM AND CLEAR STRUCTURE OF THIS MONOGRAPH MAKE THIS A LONG–AWAITED READY REFERENCE. FROM THE CONTENTS: INTRODUCTION * TECHNIQUES OF PREPARATIVE SILYLATIONS–DESILYLATIONS * PREPARATION AND PROPERTIES OF SILICONOXY–LEAVING GROUPS * REACTIONS OF FREE AND DERIVATIZED CARBOXYLIC ACIDS AND CARBON DIOXIDE * REACTIONS OF ALDEHYDES AND KETONES * REACTIONS OF ALCOHOLS, ETHERS AND EPOXIDES * REACTION OF N–O SYSTEMS * REACTIONS OF S–O AND SE–O SYSTEMS * CYCLIZATIONS AND RING ENLARGEMENTS * BASE AND ACID–CATALYZED AS WELL AS THERMAL ELIMINATIONS OF TRIMETHYLSILANOL. PETERSON REACTIONS * FORMATION OF CARBON–PHOSPHOROUS DOUBLE– AND TRIPLE BONDS * REDUCTIONS AND OXIDATIONS * DEHYDRATION–ACTIVATION AS WELL AS SILYLATION OF INORGANIC AND ORGANIC SALTS AND METALORGANIC COMPOUNDS * FORMATION OF POLYMERS

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Críticas:

"...very informative and should be of great interest to practicing organic chemists." (Journal of the American Chemical Society, October 26, 2005) "This handbook is a clear, compact compilation ... an essential practical and reference book for the research chemist." (Applied Organometallic Chemistry, May 2005)

Reseña del editor:

In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbreggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis. Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods.The compact form and clear structure of this monograph make this a long-awaited ready reference. The contents include: Introduction; Techniques of Preparative Silylations-Desilylations; Preparation and Properties of Siliconoxy-Leaving Groups; Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide; Reactions of Aldehydes and Ketones; Reactions of Alcohols, Ethers and Epoxides; Reaction of N-O Systems; Reactions of S-O and Se-O Systems; Cyclizations and Ring Enlargements; Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol; Peterson Reactions; Formation of Carbon-Phosphorous Double- and Triple Bonds; Reductions and Oxidations; Dehydration-Activation as well as Silylation of Inorganic and Organic Salts and Metalorganic Compounds; and, Formation of Polymers.

Über diese Auflage

• Verlag: Blackwell Verlag GmbH
• Erscheinungsdatum: 2004
• ISBN 10: 3527306684
• ISBN 13: 9783527306688
• Einband: Tapa dura
• Anzahl der Seiten: 378