Proteomics in Drug Research (Methods and Principles in Medicinal Chemistry, 28, Band 28) - Hardcover

Hardcover

ISBN 10: 3527312269 ISBN 13: 9783527312269

Verlag: Wiley-VCH, 2006

Inhaltsangabe

From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

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Über die Autorin bzw. den Autor

All six editors are Researchers at the Medical Proteom-Center hosted by the University of Bochum (Germany). This international research center was established in 2002 under the leadership of Helmut E. Meyer, a co-founder of the Protagen AG. Professor Meyer is also initiator and coordinator of the Human Brain Proteome Project within the German National Genome Research Net (NGFN) as well as of the Brain Proteome Project within the Human Proteome Organisation (HUPO BPP).

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By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs. From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

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Proteomics in Drug Research

John Wiley & Sons

Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
All right reserved.
ISBN: 978-3-527-31226-9

Chapter One

Administrative Optimization of Proteomics Networks for Drug Development

Andr van Hall and Michael Hamacher

Abstract

Administrative structures are gaining more and more importance in the complex world of modern science. This article will define the terms administration and networking, describing the aims and tasks of project management. The analysis of neurodegenerative diseases with proteomics technologies will be looked at from the administrative point of view with a focus on the different phases of strategy development, human resources, project control and networking. The realization of these tasks is illustrated by short presentations of a national funded network, the German Human Brain Proteome Project (HBPP) within the National Genome Research Network (NGFN), as well as of the international Brain Proteome Project of the Human Proteome Organisation (HUPO BPP).

1.1 Introduction

In modern science, the importance of administration has increased steadily over the last few decades. Nevertheless, administrative work and its influence on the success of projects as well as on financial aspects (e.g., refunding) are still undervalued in the academic field. While industry recognized the importance of organizational aspects long ago, positions responsible for administrative tasks within scientific research groups (excluding administrative departments of the universities themselves) are rare. The number of operative relative to administrative personnel is still much higher in academia than in companies (at least in Europe). As a consequence, these tasks are often done by the coordinator of a given project or one of his coworkers, who are often overloaded with work, sometimes unmotivated and mostly untrained in this field. A picture of the typical administrative research scientist as being exhausted by research, teaching and organization is emerging. In addition, staff turnover in these positions is often high, resulting in loss of knowledge, lack of continuity, and commonly, a lack of perception as to where responsibility lies. At the same time, such positions could be extremely important for the overall success of the group, e.g., in the crosslinking of basic research and commercialization.

Owing to the increasing complexity of modern science, e.g., international networking and large consortia, and the urgent need to present scientific research to the public and to the governmental project management/advisory board, a department-spanning administration should be implemented. Most research efforts in the health sciences are extremely complex and are difficult to explain to nonscientists, which often leads to misunderstanding, antipathy or even hostility from the public (e.g., see stem cell discussion, gene technologies, etc.). As the last 20 years have clearly shown, the support of a common administrative staff leads to the scientific personnel being relieved of additional work to which they are not suited, to an optimization of the scientific output (increasing added value) and to a broader acceptance in society. The need for management expansion has also been recognized by the European Union and its advisory councils, as expressed by Ernst-Ludwig Winnacker, the president of the European Heads of Research Council, in an interview with The Scientist: "The networks of excellence are big enterprises that require a great deal of management, and these have not been appreciated by scientists as much as the smaller, short-term programs that are less complex to manage and that facilitate work with smaller partners." (The Scientist online, 25 August 2004: http://www.biomedcentral.com/). The reasons for this development will be shown in the next paragraphs.

1.2 Tasks and Aims of Administration

The following chapter will present a short overview about modern scientific administration, mainly focusing on the academic side of research. To set a common starting point of what "administration" is about, the following definition is used:

The act or process of administering, especially the management of a government or large institution.

The group of people who manage or direct an institution.

Simultaneously with the increasing complexity of life science, the tasks and aims of the administration have steadily grown and evolved to a much more active management role. Originally mainly involving finances and human resources, these tasks have been joined by numerous other duties and responsibilities. Many projects demand large groups or consortia resulting in network systems (see below), thus making the organization and the feedback of teamwork as well as facilitation of the flow of information within a network an essential part of work. Additionally, interactions between the network and other national as well as international research projects, research institutions and private enterprises have to be handled. This includes so-called lobby work, the discussion with and convincing of policy makers e.g., within the European Union, to support the kind of research one advocates as the most promising approach.

Further tasks required of an administration are the composition of progress reports/business plans and final reports on schedule, the organization and calling of coordination meetings, the coordination and active participation in public relations (conferences, seminars, TV, radio, journals, etc.). This includes the planning and realization of training courses concerning technologies and topics provided by the consortium members, and the publication of the subproject results obtained at the respective time points. Moreover, (existing) homepages should be improved and optimized steadily, so that they serve not only as an information platform, but also as an interchange and communication portal.

Taken together, the administration has to

build up a network offering fast and efficient information flow;

elaborate business plans, evaluate the progress of subprojects and co-ordinate efforts;

implement infrastructures (see evaluation, Section 1.4);

serve as a central contact and administration point (added value);

increase public knowledge and acceptance of proteomics;

implement a bioinformatics infrastructure that will serve as a basis for further data base projects.

The aims of the administration - particularly in universities - are obviously to optimize processes and workflows within the respective department or network. Though implementation of controlling and monitoring could be hard to adopt in academia (in regard to the strong group autonomy), both processes are inevitably mandatory, especially in times of decreasing budgets and funding, as a consequence of which some US universities have started to gather discarded or not-required high-tech equipment from local departments and offer it to all other groups for free, avoiding unnecessary investments and expenses.

There are several other domains that have to be carefully considered when aiming at successful projects, most notably in human resources, where the generation of job specifications and the consequent identification of adequate coworkers should not be underestimated. Qualified and motivated employees who fit into the group structure are the basic requirement for planning, performing and finishing work packages in a defined schedule. These have to be generated carefully and in regard to several questions, e.g., medical need, potential return of investment, proof...

Details zur Ausgabe

• Verlag: Wiley-VCH
• Erscheinungsdatum: 2006
• Sprache: Englisch
• ISBN 10: 3527312269
• ISBN 13: 9783527312269
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 383
• Herausgeber: Hamacher Michael, Marcus Katrin, Stühler Kai, Van Hall Andre, Warscheid Bettina, Meyer Helmut E.
• Kontakt zum Hersteller: Wiley-VCH GmbH; product_safety@wiley.com; ; Boschstrasse 12; Weinheim; 69469; Deutschland