This book not only introduces the reader to the necessary tools to understand microbiome but also discusses many relevant areas of current research and applications of microbiome engineering, ranging from human diseases to husbandry, food and beverage applications.
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Matthew Chang is Associate Professor in Biochemistry in the Yong Loo Lin School of Medicine at the National University of Singapore (NUS), and Director of the Singapore Consortium for Synthetic Biology (SINERGY), Wilmar-NUS Corporate Laboratory (Wil-NUS) and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI). His research interests lie in the development of biological systems that perform programmable functions. In particular, he has pioneered the development of microbial cells programmed to perform targeted therapeutic functionalities. His scientific contributions have been recognized with international honours and awards, including the Scientific and Technological Achievement Award from U.S. Environmental Protection Agency, and featured in leading media outlets worldwide. He serves as an editor and an editorial board member for a number of journals including Cell Systems, Metabolic Engineering, Biotechnology for Biofuels, ACS Synthetic Biology, and Critical Reviews in Microbiology. He serves on the advisory committee of key international research programs such as the Synthetic Biology Open Language (SBOL) and CSIRO Future Science Platform.
Provides an overview of the techniques and applications insight into the complex composition and interactions of microbiomes
Microbiomes, the communities of microorganisms that inhabit specific ecosystems or organisms, can be engineered to modify the structure of microbiota and reestablish ecological balance. In recent years, a better understanding of microbial composition and host-microbe interactions has led to the development of new applications for improving human health and increasing agricultural productivity and quality.
Principles in Microbiome Engineering introduces readers to the tools and applications involved in manipulating the composition of a microbial community to improve the function of an eco-system. Covering a range of key topics, this up-to-date volume discusses current research in areas such as microbiome-based therapeutics for human diseases, crop plant breeding, animal husbandry, soil engineering, food and beverage applications, and more. Divided into three sections, the text first describes the critical roles of systems biology, synthetic biology, computer modelling, and machine learning in microbiome engineering. Next, the volume explores various state-of-the-art applications, including cancer immunotherapy and prevention of diseases associated with the human microbiome, followed by a concluding section offering perspectives on the future of microbiome engineering and potential applications.
Edited and authored by leading researchers in the rapidly evolving field, Principles in Microbiome Engineering is an essential resource for biotechnologists, biochemists, microbiologists, pharmacologists, and practitioners working in the biotechnology and pharmaceutical industries.
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