Verwandte Artikel zu Nitrates III: Cardiovascular Effects
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Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).
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Nitrates III. Cardiovascular effects. Mit 326 Tabellen und Illustrationen.
Anbieter: Antiquariat Bibliakos / Dr. Ulf Kruse, Kiel, Deutschland
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Edited by P. R. Lichtlen / H.-J. Engel / A. Schrey / H. J. C. Swan. Nitrates III. Cardiovascular effects. Springer-Verlag. Berlin/Heidelberg/New York 1981. XX, 597 S. mit 326 Tabellen und Illustrationen. Original-Ganzleinen mit Rücken- und Deckeltitel nebst Original-Schutzumschlag mit Innentext. Zustand: Von sehr guter Erhaltung. Ungelesen. Keine Remittende. [SW: Nitrates, Pharmacodynamics + Kinetics, Hemodynamics, Coronary Flow, Perfusion, Vascular Effects, Pulmonary Circulation, Myocordail Infarction, Angina, Exercise, Heart Failure, Bypass Surgery, Valvular Heart Disease] Sprache: en 1322 Gramm. Bestandsnummer des Verkäufers CM-027
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Nitrates III: Cardiovascular Effects
Anbieter: Bookbot, Prague, Tschechien
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Hardcover. Zustand: Fine. Leichte Anmerkungen / Beschriftungen. Pharmacological and clinical research on nitrates remains a focal point of interest, despite their beneficial effects in angina pectoris being recognized over a century ago. Since the last symposia on nitrates in 1975 and 1978, significant new information has emerged regarding their pharmacology, pharmacokinetics, and pharmacodynamics, as well as their clinical implications in acute and chronic ischemic heart diseases and severe congestive heart failure. However, advancements in understanding the fundamental action of nitrates have been limited. While it is widely accepted that nitrates reduce vascular smooth muscle tone primarily through intracellular calcium sequestration, the precise site of action is still unclear. Established differences in venous and arteriolar tone based on dosage have been noted. Treatment discussions highlighted the issue of tolerance with long-term use, introducing the concept of "pseudotolerance" to explain the body's adaptation to chronic vasodilation. This understanding is crucial for long-term prophylactic anti-ischemic treatment in both stable and unstable angina pectoris, particularly during episodes of increased vasomotor tone, such as spasm. Bestandsnummer des Verkäufers 79b94557-a471-4218-b7f6-36c04afdc18f
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Nitrates III: Cardiovascular Effects Paul R. Lichtlen
Anbieter: BUCHSERVICE / ANTIQUARIAT Lars Lutzer, Wahlstedt, Deutschland
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Hardcover. Zustand: gut. 1981. Nitrates III: Cardiovascular Effects In deutscher Sprache. pages. Bestandsnummer des Verkäufers BN705832
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