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Redesigning the Molecules of Life: Conference Papers of the International Symposium on Bioorganic Chemistry Interlaken, May 4-6, 1988 - Softcover

 
9783540191667: Redesigning the Molecules of Life: Conference Papers of the International Symposium on Bioorganic Chemistry Interlaken, May 4-6, 1988
Softcover
ISBN 10: 3540191666 ISBN 13: 9783540191667
Verlag: Springer Berlin Heidelberg, 1988

Inhaltsangabe

The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.

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The organic chemist is rarely satisfied by a simple "explanation" of the reactivity of organic molecules. Rather, the chemist wants to go one step further, to "control" the behavior of molecules by altering their structure in a controlled way. This is, in fact, a rather stringent definition of "understanding," as it requires the "prediction" of behavior from structure (or structure from behavior). But it also places technical demands on the chemist. He must be able to synthesize the molecules he studies, characterize them at the atomic level of structural resolution, and then measure their behaviors to the precision that his explanation demands. Biological chemistry presents special problems in this regard. Although the tools for synthesis, purification, and structural characterization are now available for manipulating rather large biological macromolecules (proteins and nucleic acids in particular), the theory supporting these manipulations is inadequate. We certainly do not know enough to control generally the behavior of biological macromolecules; still worse, it is not clear that we know enough to design synthetic molecules to expand our understanding about how reactivity in such biological macromolecules might be controlled. Starting from scratch, there are simply too many oligopeptides to make; starting from native proteins, there are simply too many structural mutations that might be introduced.

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Verlag
Springer Berlin Heidelberg
Erscheinungsdatum
1988
Sprache
Englisch
ISBN 10 
3540191666
ISBN 13 
9783540191667
Einband
Taschenbuch
Auflage
1
Anzahl der Seiten
182
Herausgeber
Benner Steven A.
Kontakt zum Hersteller
Springer Netherlands
buchhandel-buch@springer.com

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