The Europäische Akademie Bad Neuenahr-Ahrweiler GmbH is concerned with the scientific study ofthe consequences of scientific and technological advance for the individual, society and the natural environment and, therefore, not least with the study of consequences of recent developments in life-sciences and medical disci plines. The Europäische Akademie intends to contribute to find a rational way for society to deal with the consequences of scientific progress. This aim is mainly realised by proposing recommendations for options of action with long-term social acceptance. The work of the Europäische Akademie mostly takes place in tempo rary interdisciplinary project groups, whose members are recognised scientists from European universities and other independent institutes. In the light of recent discussions on the validity of scientific assumptions con cerning the extrapolation ofharmful effects into the low-dose range the Europäis che Akademie set up a project on "Lew-Dose Exposures in the Environment their Risk Assessments and Regulatory Processes" in January 2001. Experts ofradiobi ology, toxicology, medical epidemiology, modelling,jurisprudence, psychology and philosophy from different European countries wcre brought together to discuss cur rent scientific developments in environmental standard setting and risk evaluation of substances and ionising radiation at very low doses in order to ensure rational, efficient, and fair decisions. I am glad that by means ofthis memorandum, that continues our work on envi ronmental standards and after our recommendations with respect to the regulation ofcombined agents we can now focus on the effects and the regulation ofharmful agents in the very low-dose range.
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The ever-increasing release of harmful agents due to human activities have led in some areas of the world to heavy pollution. In order to protect human health and the environment, environmental standards that shall limit the release and the concentration of those toxic agents in the environment and hence the exposure to it have to be established. The related assessment and decision-making procedures have to be based on solid scientific data about the effects and mechanisms of these agents as well as on ethical, social and economic aspects. For risk evaluation, the knowledge of the dose response curve is an essential prerequisite. Dose responses without a threshold dose are most critical in this connection. Such dose responses are assumed for mutagenic and carcinogenic effects, which, therefore, dominate also the discussion in this book. In the environmentally important low dose range, risk estimation can only be achieved by extrapolation from higher doses with measurable effects. The extrapolation is accompanied with uncertainties which makes risk evaluation as well as risk communication frequently problematic. In order to ensure rational efficient and fair decisions beyond a sound scientific assessment the dialogue between disciplines, with the affected people and with the general public is necessary. In this book, the whole range of relevant and essential aspects of risk evaluation and standard setting is addressed. Starting with the ethical foundations, the sound analysis of recent scientific findings sets the frame for further reflections by theory of cognition, psychosocial sciences, and jurisprudence. The authors end up with concluding recommendations for coping with the recent problems of standard setting in the field of environmentally relevant low doses. The book is designed to a readership of scientists, legislators, administrators, and the interested public.
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Hardcover. Zustand: Good. Hardcover, 470pp, NOT ex-library. Clean book, with unmarked text, no stamps. A small indentation to some lower outer page corners. Handling marks on boards; rubbed upper front board at spine. Issued without a dust jacket. -- Contents: Ethical Aspects of Risk [Rational Decision Making (Decision Makers; Alternatives; Probabilities of Consequences. Precautionary Principle; Utilitarianism & Consequentialism; Values; Time; Life; Health; Environmental Values; Known Individuals or Anonymous Ones; Free Choice; Consent; Distribution; Compensation; Background Exposure; Value of Actions; Comparison of Values. Ultimate Justification); Implementation: Ethics, Law & Economics]; Effects of Ionising Radiation in Low-Dose Range: Radiobiological Basis [What Is a Low Dose? (Microdosimetric & Biological Considerations); DNA Damage & Repair; Cellular Damages (Chromosomal Aberrations; Cell Transformation; Gene Mutations in Somatic Cells; Modifying Phenomena); Animal Experiments (Carcinogenesis & Life Shortening; Hereditary Diseases)]; Toxicology of Chemical Carcinogens [General Concepts & Dose-Response Relationships; Modifiers of Dose-Response of the Curve; Endogenous Chemical Carcinogens; Examples of Carcinogens & Modifiers Leading to Different Dose-Response Types (Vinyl Chloride; Aflatoxin B1; N,N-Diethylnitrosamine DEN; NNK (4-[N-methyl-N-nitrosoamino]-1-[3-pyridyl]-1-butanone); 2-Acetylaminofluorene 2-AAF; Arsenic; 4-Aminobiphenyl 4-ABP; Formaldehyde; Vinyl Acetate; Non DNA-Reactive Genotoxins; Non-Genotoxic Carcinogens); Interspecies Extrapolation; Interindividual Variations of Toxicological Response in Human Population (Age (Children); Relevance of Polymorphisms for Low-Dose Exposures)]; Epidemiological Perspectives on Low-Dose Exposure to Human Carcinogens [(Epidemiological Considerations & Methods; Relative & Absolute Risk Estimates; Biostatistical Considerations); Ionising & Non-Ionising Radiation (UV-light; Mobile Phones; Other Electro-Magnetic Fields); Smoking; Other Potential Carcinogenic Compounds (Insecticides; Industrial Chemicals & Waste & Emissions; Asbestos)]; Mathematical Models of Carcinogenesis [(Models of Carcinogenesis; Hazard & Excess Risk); Models Without Clonal Expansion; Models with Clonal Expansion; Ionising Radiation (Effects of Inhaled Radon Progeny; Effects of External Exposures; Low-Dose Radiobiological Effects & Risk Estimation); Carcinogenic Substances (Replication & Apoptosis of Intermediate Cells in Hepatocarcinogenesis; Combined Effects of an Initiating & Promoting Agent on Hepatocarcinogenesis; Lung Cancer Due to Coke Oven Emissions); Ionising Radiation & Carcinogenic Substances (Radon, Smoking, Arsenic; Low-Dose Risk After Exposure to an Initiating & Promoting Agent); Likelihood, Model Fits & Deviance]; Comparing Summary of Action of Ionising Radiation & Chemicals in Carcinogenesis; Hypothesis Testing & the Choice of Dose-Response Model [Uncertainties in Dose-Response Modelling (Extrapolation; Thresholds); Theories of Science (Hypothetico-Deductive Method; Laws, Hypotheses, Theories & Models: Differences Between Biology & Physics; Choosing Between Alternative Hypotheses; Popperian Falsification; Safety, Strength & Simplicity; Ad Hoc Hypothesis; Scientific Plausibility & Standards of Proof; Choice of Hypothesis in Science & for Policy]; Risk Evaluation & Communication [Risk Analysis (Definitions; Risk Assessment & Characterisation; Uncertainty, Precautionary Principle & Governance; Risk Management; Comparative Aspects of Interpreting Risks); Communication of Information on Risk]; Low Doses in Health-Related Environmental Law [Legal Framework; Risk Assessment, Low Doses & Environmental Law; Risk Assessment: Science & Law; Decision on the Tolerability of Exposure to Low Doses & Measures to Prevent or Reduce Risks; Organisation of the Decision-Making Process]; Summary; Zusammenfassung; Recommendations for Environmental Risks to Human Health: Evaluation & Regulatory Processes; Glossary]. Bestandsnummer des Verkäufers 004659
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Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The ever-increasing release of harmful agents due to human activities have led in some areas of the world to heavy pollution. In order to protect human health and the environment, environmental standards that shall limit the release and the concentration of those toxic agents in the environment and hence the exposure to it have to be established. The related assessment and decision-making procedures have to be based on solid scientific data about the effects and mechanisms of these agents as well as on ethical, social and economic aspects. For risk evaluation, the knowledge of the dose response curve is an essential prerequisite. Dose responses without a threshold dose are most critical in this connection. Such dose responses are assumed for mutagenic and carcinogenic effects, which, therefore, dominate also the discussion in this book. In the environmentally important low dose range, risk estimation can only be achieved by extrapolation from higher doses with measurable effects. The extrapolation is accompanied with uncertainties which makes risk evaluation as well as risk communication frequently problematic. In order to ensure rational efficient and fair decisions beyond a sound scientific assessment the dialogue between disciplines, with the affected people and with the general public is necessary. In this book, the whole range of relevant and essential aspects of risk evaluation and standard setting is addressed. Starting with the ethical foundations, the sound analysis of recent scientific findings sets the frame for further reflections by theory of cognition, psychosocial sciences, and jurisprudence. The authors end up with concluding recommendations for coping with the recent problems of standard setting in the field of environmentally relevant low doses. The book is designed to a readership of scientists, legislators, administrators, and the interested public. 492 pp. Englisch. Bestandsnummer des Verkäufers 9783540210832
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HARDBACK. Zustand: FINE ( AS NEW). No Jacket. 68 Figures and 28 Tables (illustrator). This book is part of a large purchase from a Public Sector Library and except where mentioned are for the most part LIKE NEW! MOSTLY the ONLY flaws are the blacked out (they insisted) Library stamps which show many of them to be UNUSED! FEEL FREE TO E-MAIL FOR PHOTOGRAPHS AND FURTHER DETAILS. FROM A DEALER WHO TELLS YOU WHO THEY ARE AND WHAT THEIR TELEPHONE AND ADDRESS CONTACT DETAILS ARE! Size: 8vo - over 7¾" - 9¾". EX PUBLIC SECTOR LIBRARY BLACK. Bestandsnummer des Verkäufers 33333333947
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