Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone - Hardcover

Buehler, Volker; Bhler, Volker; Buhler, Volker

9783540234128: Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

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ISBN 10: 3540234128 ISBN 13: 9783540234128

Verlag: Springer, 2004

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The book describes the properties, analytical methods and the applications of different polyvinylpyrrolidone excipients (povidone, crospovidone, copovidone etc.) for use in pharmaceutical preparations. This group of excipients is one of the most important excipients used in modern technology to produce drugs. The book is intended for all persons working in the research, development and quality control of drugs. It gives a survey of all applications in solid, liquid and semisolid dosage forms including many drug formulation examples and more than 600 references to the literature.

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VerlagSpringer
Erscheinungsdatum2004
ISBN 10 3540234128
ISBN 13 9783540234128
EinbandTapa dura
Anzahl der Seiten266

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9783642062438: Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

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ISBN 10: 3642062431 ISBN 13: 9783642062438
Verlag: Springer, 2010
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Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

Volker Buhler

Verlag: Springer, 2004

ISBN 10: 3540234128 ISBN 13: 9783540234128

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Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

Volker Buhler

Verlag: Springer, 2004

ISBN 10: 3540234128 ISBN 13: 9783540234128

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Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

B�hler, Volker

Verlag: Springer, 2004

ISBN 10: 3540234128 ISBN 13: 9783540234128

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Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone

Volker B�hler

Verlag: Springer, 2005

ISBN 10: 3540234128 ISBN 13: 9783540234128

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Hardcover. Zustand: Near Fine. Hardcover, vii + 254 pages, NOT ex-library. Printed in Germany (not an economy / Indian edition). Clean and bright throughout with unmarked text, free of inscriptions and stamps, firmly bound. Rear board shows minor indentations to edges. Published without a dust jacket. -- Contents: 1 General notes on synthesis [Soluble polyvinylpyrrolidone (Povidone); Insoluble polyvinylpyrrolidone (Crospovidone); Vinylpyrrolidone-vinyl acetate copolymer (Copovidone)] 2 Soluble polyvinylpyrrolidone (Povidone) [Structure, product range, synonyms; Product properties - Description, specifications, pharmacopoeias - Solubility, dissolution - Viscosity, K-value - Particle size, particle structure, bulk density - Hygroscopicity - Molecular weight - Complexation, chemical reactions - Osmotic pressure, sterilization by filtration (low-molecular povidone) - Stability, storage; Analytical methods for povidone - Qualitative and quantitative methods of determination - Methods for the determination of the K-value and molecular weight - Methods for the determination of purity - Determination of povidone in preparations; Applications of povidone - General properties - Binders for tablets, granules and hard gelatin capsules - Improvement of the dissolution rate and bioavailability of drugs - Tablet coatings - Improvement of the solubility of drugs (solubilization) - Suspensions, dry syrups and instant granules - Applications in ophthalmic solutions - Sustained-release preparations - Miscellaneous applications] 3 Insoluble polyvinylpyrrolidone (Crospovidone) [Structure, product range, synonyms; Properties of crospovidone - Description, specifications, pharmacopoeias - Particle size, bulk density - Specific surface area, water absorption - Swelling - Complexation, chemical interaction - Stability, storage, packaging; Analytical methods for crospovidone - Qualitative and quantitative methods of determination - Methods for the determination of purity - Determination of complexation capacity with salicylic acid - Quantitative determination of crospovidone in preparations; Applications of crospovidone - General application properties - Crospovidone as disintegrant and dissolution agent for tablets, granules and hard gelatin capsules - Improvement of the dissolution and bioavailability of drugs with crospovidone - Micronized crospovidone of low bulk density as a stabilizer for oral and topical suspensions - Micronized crospovidone as an active substance - Miscellaneous applications] 4 Vinylpyrrolidone-vinyl acetate copolymer (Copovidone) [Structure, synonyms; Product properties - Description, specification, pharmacopoeias - Solubility - Viscosity, K-value, molecular weight - Physical properties of the powder - Stability, storage, packaging; Analytical methods - Qualitative and quantitative methods of determination - Methods for the determination of purity - Determination of copovidone in preparations; Applications of copovidone - General notes - Binder for tablets, granulates and hard gelatin capsules - Tablet coatings - Film-forming agent in sprays - Matrix-forming agent in sustained-release and fast-release dosage forms - Transdermal and transmucosal systems] 5 Registration and toxicological data [Registration - Pharmaceutical products - Food; Toxicological data - Povidone and Crospovidone - Copovidone]; Literature references; Alphabetical index. Bestandsnummer des Verk�ufers 005172

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