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Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology, 44, Band 44) - Hardcover

Buch 6 von 31: Progress in Molecular and Subcellular Biology
 
9783540344483: Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology, 44, Band 44)
Hardcover
ISBN 10: 3540344489 ISBN 13: 9783540344483
Verlag: Springer, 2006

Inhaltsangabe

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

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Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

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Verlag
Springer
Erscheinungsdatum
2006
Sprache
Englisch
ISBN 10 
3540344489
ISBN 13 
9783540344483
Einband
Gebundene Ausgabe
Anzahl der Seiten
269
Herausgeber
Jeanteur Philippe
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