Biology of Aging (Progress in Molecular and Subcellular Biology, Band 30) - Hardcover

Hardcover

ISBN 10: 3540438270 ISBN 13: 9783540438274

Verlag: Springer, 2002

Inhaltsangabe

The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.

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This volume gives the reader a comprehensive overview of the fundamental and biological aspects of aging. First, the field is described from a historical perspective. Then, the author analyzes the three fundamental mechanisms of survival: energy utilization, molecular and cellular redundancy, and the organization of information. The genetics of aging is reviewed rejecting some simple-minded interpretations. A bridge is established between the molecular, cellular, and tissue modifications that have been reported in the literature, and the clinical manifestations of the aging syndrome. Special relevance is given to the problem of the supposed association between cancers and aging, giving a new interpretation of that relationship.

Details zur Ausgabe

• Verlag: Springer
• Erscheinungsdatum: 2002
• Sprache: Englisch
• ISBN 10: 3540438270
• ISBN 13: 9783540438274
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 200
• Herausgeber: Macieira-Coelho Alvaro
• Kontakt zum Hersteller: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Tiergartenstr. 17; Heidelberg; 69121; Deutschland