History and early investigation on mode of action of peroxi- dizing herbicides; Structural evolution and synthesis of di- phenyl ethers, cyclic imides and related compounds; Recent advances in peroxidizing herbicides (patent overview); Structure/activity relationship and molecular design of her- bicides with cyclic imide and related structures; Structure /activity relationship of diphenyl ethers and other oxygen- bridged protoporphyrinogen oxidase inhibitors; General phy- siological characteristics and mode of action of peroxidi- zing herbicides; Metabolic modification of isoimide-type per oxidizing compounds; The metabolic pathway of tetrapyrrole biosynthesis; Characteristics of protoporphyrinogen oxidase; Assay systems for peroxidizing herbicides; Herbicidal effi- cacy of protoporphyrinogen oxidase inhibitors; Antagonizing peroxidizing herbicides; Strategy for peroxidizing herbicide resistant crops; Metabolism and degradation of porphyrin biosynthesis inhibitor herbicides; Toxicology of peroxidi- zing herbicides to mammals and non-target organisms
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Experts in herbicide research and development - chemists and plant physiologists -, have written 15 chapters that review all aspects pertinent to peroxidizing herbicides, compounds of topical interest since extremely low use rates ensure high environmental safety. Topics covered include structure-activity relationships, relevant patent literature, preparative methods, modes of action, greenhouse screening, laboratory assays, plant pigment biochemistry, and enzymology of the decisive target enzyme of this class of herbicides. This comprehensive review will be welcomed as a unique and timely compilation of the current status of peroxidizing herbicide research and development. It will be of interest to professional chemists and biologists in agrochemical companies, universities and agricultural colleges.
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