In vitro development of islets from human adult pancreatic tissues; .: An alternative source for clinical islet transplantation - Softcover

Gao, Ru

 
9783639087482: In vitro development of islets from human adult pancreatic tissues; .: An alternative source for clinical islet transplantation
Softcover
ISBN 10: 3639087488 ISBN 13: 9783639087482
Verlag: VDM Verlag Dr. Müller, 2008

Inhaltsangabe

Transplantation of isolated islets from cadaverpancreas is a promising possibility for the optimaltreatment of type 1 diabetes. However, such anapproach is severely limited by the shortage ofdonor organs. And also the long-term function ofhuman pancreatic islet grafts may depend on theneogenesis of beta cells from epithelial precursorswithin the grafted tissue. Islet neogenesis can beinduced in adult mouse and human pancreatic ductalcell cultures. Using the in vitro model for humanislet neogenesis, we confirm the capacity ofendocrine differentiation from progenitors presentin the adult human pancreas. Ductal celldifferentiation into endocrine cells in transplantedislets may be an important factor in sustaining thelong-term function of islet transplants. Theimmunosuppressive protocol appears to be animportant determinant of long-term clinical isletgraft function. Besides the specific descriptions onislet regeneration, this book also provides basicknowledge on the histology of pancreas and islets aswell as the development of pancreas, which should beuseful to both professionals in diabetes researchfield and ordinary readers.

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Verlag
VDM Verlag Dr. Müller
Erscheinungsdatum
2008
Sprache
Englisch
ISBN 10 
3639087488
ISBN 13 
9783639087482
Einband
Taschenbuch
Anzahl der Seiten
76
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Zeitfracht Medien GmbH
info-medien@zeitfracht.de

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Erfurt
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