Computational Systems Biology with Constraints - Softcover

Bortolussi, Luca

 
9783639088755: Computational Systems Biology with Constraints
Softcover
ISBN 10: 3639088751 ISBN 13: 9783639088755
Verlag: VDM Verlag Dr. Mueller e.K., 2008

Inhaltsangabe

Recently, stochastic process algebras have been used for modeling biological systems, as they provide a simple, compositional language to define biological models. Classical process algebras, however, require to express everything in terms of communications, a limiting restriction when structured information needs to be processed. In this book, we tackle this problem using a more general language and programming it to deal with the domain of interest. Specifically, we introduce a sto­chastic extension (sCCP) of Concurrent Constraint Programming. It is precisely the use of constraints that gives flexibility and extendibility to the language, together with the presence of context-dependent stochastic rates. To prove this, we show how sCCP can be used to model a wide range of biological systems, from biochemical networks to the process of folding of a protein, providing evidence that the use of constraints simplifies the process of modeling and allows to incorporate external knowledge. Many analysis tools are developed: stochastic simulation, model checking, ODE-based approximations. The book can be of interest to researchers working in the field of computational systems biology.

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Reseña del editor

Recently, stochastic process algebras have been used for modeling biological systems, as they provide a simple, compositional language to define biological models. Classical process algebras, however, require to express everything in terms of communications, a limiting restriction when structured information needs to be processed. In this book, we tackle this problem using a more general language and programming it to deal with the domain of interest. Specifically, we introduce a sto­chastic extension (sCCP) of Concurrent Constraint Programming. It is precisely the use of constraints that gives flexibility and extendibility to the language, together with the presence of context-dependent stochastic rates. To prove this, we show how sCCP can be used to model a wide range of biological systems, from biochemical networks to the process of folding of a protein, providing evidence that the use of constraints simplifies the process of modeling and allows to incorporate external knowledge. Many analysis tools are developed: stochastic simulation, model checking, ODE-based approximations. The book can be of interest to researchers working in the field of computational systems biology.

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Verlag
VDM Verlag Dr. Mueller e.K.
Erscheinungsdatum
2008
Sprache
Englisch
ISBN 10 
3639088751
ISBN 13 
9783639088755
Einband
Tapa blanda
Anzahl der Seiten
248
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Nicht verfügbar
Verantwortliche Person
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