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INSIDE THE PLASMA AMINE OXIDASE: PRELIMINARY DRUG DISCOVERY STUDY OF PLASMA AMINE OXIDASE: STRUCTURAL BASIS OF SUBSTRATE AND INHIBITORY ACTIVITY OF BOVINE PLASMA AMINE OXIDASE - Softcover

Chen, Yanwen

 
9783639255683: INSIDE THE PLASMA AMINE OXIDASE: PRELIMINARY DRUG DISCOVERY STUDY OF PLASMA AMINE OXIDASE: STRUCTURAL BASIS OF SUBSTRATE AND INHIBITORY ACTIVITY OF BOVINE PLASMA AMINE OXIDASE
Softcover
ISBN 10: 3639255682 ISBN 13: 9783639255683
Verlag: VDM Verlag Dr. Müller, 2010

Inhaltsangabe

The copper-containing amine oxidases, like bovine plasma amine oxidase (BPAO), carry out a transaminative oxidation of primary amines to aldehydes via use of an active site Tyr-derived 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. Propargylamine is a potent inactivator of BPAO (IC50 = 3 µM), possibly through active-site modification by the a,ß-unsaturated aldehyde turnover product, but the simple structure is expected to confer low selectivity. On the basis of the finding by previous students that certain extended conjugation analogs such as 1,6-diamino-2,4- hexadiyne and 3-cyanopropargylamine preserve strong inactivation potency, other extended conjugation analogs of propargylamine were evaluated. In particular, 1-amino-2,4-hexadiynes with a 6-OH rather than 6-NH2 group were found to be potent inhibitors.

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Verlag
VDM Verlag Dr. Müller
Erscheinungsdatum
2010
Sprache
Englisch
ISBN 10 
3639255682
ISBN 13 
9783639255683
Einband
Taschenbuch
Anzahl der Seiten
216
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland