Arbidol: an antiviral against globally prevalent viruses [Libro en inglés] - Softcover

Pécheur, Eve-Isabelle; Polyak, Stephen J.

Softcover

ISBN 10: 3639653467 ISBN 13: 9783639653465

Verlag: Éditions universitaires européennes, 2017

Über diesen Titel

Reseña del editor:

Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.

Biografía del autor:

Eve-Isabelle Pécheur (Pharm.D. - Ph.D.) is group leader CNRS at the Cancer Research Center of Lyon, France. Her main research interests are the role of the liver microenvironment in hepatitis B and C pathogenesis, and the discovery of novel antiviral strategies. She is the author of 60 publications.

Über diese Auflage

• Verlag: Éditions universitaires européennes
• Erscheinungsdatum: 2017
• ISBN 10: 3639653467
• ISBN 13: 9783639653465
• Einband: Tapa blanda
• Anzahl der Seiten: 116