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Reactive structural plasticity of climbing fibres after laser axotomy: In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex - Softcover
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The regenerative properties of neurons in the adult brain are generally very poor. Nonetheless, few populations of neurons, like the object of this study, retains regrowth capacities in adult being. This book is focused on the regenerative properties of adult cerebellar neurons. This study exploit high energy pulsed lasers to dissect single neuronal branches. In vivo two-photon imaging allows monitoring the remodeling of the dissected neuron on the long term with subcellular resolution. We found that climbing fibers (a type of cerebellar axons) are capable of regrowing after laser dissection of single axonal branches and that the regrowth of new branches from the injured neurons requires the expression of a growth associated protein, GAP-43. Axonal degeneration and modifications in GAP-43 expression profiles are associated with a plethora of neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, diabetic neuropathy, schizophrenia and Alzheimer s and Parkinson s diseases. In this respect, these results may be helpful in assessing and validating new therapeutic strategies to prevent degeneration and promote axonal regrowth.
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Über die Autorin bzw. den Autor
I graduated in Chemistry of Biological Molecules 110/110 cum laude in 2007, then in 2010 I got the PhD on Biophysics at the University of Florence, Italy. My main research interest is neuronal plasticity, both structural and functional, and in detail how it can trigger the recovery of injured brain areas.
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Reactive structural plasticity of climbing fibres after laser axotomy
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The regenerative properties of neurons in the adult brain are generally very poor. Nonetheless, few populations of neurons, like the object of this study, retains regrowth capacities in adult being. This book is focused on the regenerative properties of adult cerebellar neurons. This study exploit high energy pulsed lasers to dissect single neuronal branches. In vivo two-photon imaging allows monitoring the remodeling of the dissected neuron on the long term with subcellular resolution. We found that climbing fibers (a type of cerebellar axons) are capable of regrowing after laser dissection of single axonal branches and that the regrowth of new branches from the injured neurons requires the expression of a growth associated protein, GAP-43. Axonal degeneration and modifications in GAP-43 expression profiles are associated with a plethora of neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, diabetic neuropathy, schizophrenia and Alzheimer s and Parkinson s diseases. In this respect, these results may be helpful in assessing and validating new therapeutic strategies to prevent degeneration and promote axonal regrowth. 116 pp. Englisch. Bestandsnummer des Verkäufers 9783639700343
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Reactive structural plasticity of climbing fibres after laser axotomy : In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The regenerative properties of neurons in the adult brain are generally very poor. Nonetheless, few populations of neurons, like the object of this study, retains regrowth capacities in adult being. This book is focused on the regenerative properties of adult cerebellar neurons. This study exploit high energy pulsed lasers to dissect single neuronal branches. In vivo two-photon imaging allows monitoring the remodeling of the dissected neuron on the long term with subcellular resolution. We found that climbing fibers (a type of cerebellar axons) are capable of regrowing after laser dissection of single axonal branches and that the regrowth of new branches from the injured neurons requires the expression of a growth associated protein, GAP-43. Axonal degeneration and modifications in GAP-43 expression profiles are associated with a plethora of neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, diabetic neuropathy, schizophrenia and Alzheimer s and Parkinson s diseases. In this respect, these results may be helpful in assessing and validating new therapeutic strategies to prevent degeneration and promote axonal regrowth. Bestandsnummer des Verkäufers 9783639700343
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Reactive Structural Plasticity of Climbing Fibres After.
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Reactive Structural Plasticity of Climbing Fibres After.
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Reactive Structural Plasticity of Climbing Fibres After.
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Reactive structural plasticity of climbing fibres after laser axotomy
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The regenerative properties of neurons in the adult brain are generally very poor. Nonetheless, few populations of neurons, like the object of this study, retains regrowth capacities in adult being. This book is focused on the regenerative properties of adult cerebellar neurons. This study exploit high energy pulsed lasers to dissect single neuronal branches. In vivo two-photon imaging allows monitoring the remodeling of the dissected neuron on the long term with subcellular resolution. We found that climbing fibers (a type of cerebellar axons) are capable of regrowing after laser dissection of single axonal branches and that the regrowth of new branches from the injured neurons requires the expression of a growth associated protein, GAP-43. Axonal degeneration and modifications in GAP-43 expression profiles are associated with a plethora of neurological diseases, including amyotrophic lateral sclerosis, multiple sclerosis, epilepsy, diabetic neuropathy, schizophrenia and Alzheimer's and Parkinson's diseases. In this respect, these results may be helpful in assessing and validating new therapeutic strategies to prevent degeneration and promote axonal regrowth.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch. Bestandsnummer des Verkäufers 9783639700343
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Reactive structural plasticity of climbing fibres after laser axotomy | In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex
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Taschenbuch. Zustand: Neu. Reactive structural plasticity of climbing fibres after laser axotomy | In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex | Anna Letizia Allegra Mascaro | Taschenbuch | Paperback | 116 S. | Englisch | 2014 | SPS | EAN 9783639700343 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 105117423
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Reactive Structural Plasticity of Climbing Fibres After Laser Axotomy
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