Tetrahydro Pyrimidines - Softcover

Vyas, Kartik; Nimavat, Kiran; Joshi, Kaushik

 
9783639713855: Tetrahydro Pyrimidines
Softcover
ISBN 10: 3639713850 ISBN 13: 9783639713855
Verlag: Scholars' Press, 2014

Inhaltsangabe

Generally pyrimidine derivatives such as 2-hydroxy-substitutedpyrimidine, 2-mercapto-substituted-pyrimidine and 2-amino-substituted pyrimidine are studied. Pyrimidines have been isolated from the nucleic acid hydrolysates. Pyrimidines are among those molecules that make life possible, have been some of the building blocks of DNA and RNA. Several analogues of pyrimidines have been used as compounds that interfere with the synthesis and functioning of nucleic acids e.g. fluorouracil, which has been used in cancer treatment. Modifications in the base, sugar and phosphate moieties of oligonucleotides and oligonucleotide conjugates have been reported. The subjects of medicinal chemical programmes include approaches to create enhanced affinity and more selective affinity for RNA or duplex structures, the ability to cleave nucleic acid targets, enhanced nuclease stability, cellularuptake and distribution, in vivo tissue distribution, metabolism and clearance.

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Reseña del editor

Generally pyrimidine derivatives such as 2-hydroxy-substitutedpyrimidine, 2-mercapto-substituted-pyrimidine and 2-amino-substituted pyrimidine are studied. Pyrimidines have been isolated from the nucleic acid hydrolysates. Pyrimidines are among those molecules that make life possible, have been some of the building blocks of DNA and RNA. Several analogues of pyrimidines have been used as compounds that interfere with the synthesis and functioning of nucleic acids e.g. fluorouracil, which has been used in cancer treatment. Modifications in the base, sugar and phosphate moieties of oligonucleotides and oligonucleotide conjugates have been reported. The subjects of medicinal chemical programmes include approaches to create enhanced affinity and more selective affinity for RNA or duplex structures, the ability to cleave nucleic acid targets, enhanced nuclease stability, cellularuptake and distribution, in vivo tissue distribution, metabolism and clearance.

Biografía del autor

Dr. Kartik B. Vyas M. Sc. , Ph. D.,(Chemistry) F. I. C. C.,F. I. C. S. professor, Sheth L. H. Science College,Mansa, Gujarat(India). Ten students completed theirPh. D. Degree by his guidance.

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Verlag
Scholars' Press
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3639713850
ISBN 13 
9783639713855
Einband
Tapa blanda
Anzahl der Seiten
124
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