Diffusion-Reaction Modeling,Nonlinear Dynamics,Feedback,Bifurcation and Chaotic Behavior: of the Acetylcholine Neurocycle and their Relation to Alzheimer's and Parkinson's Diseases - Softcover

Mustafa, Ibrahim

 
9783639864205: Diffusion-Reaction Modeling,Nonlinear Dynamics,Feedback,Bifurcation and Chaotic Behavior: of the Acetylcholine Neurocycle and their Relation to Alzheimer's and Parkinson's Diseases
Softcover
ISBN 10: 3639864204 ISBN 13: 9783639864205
Verlag: VDM Verlag, 2018

Inhaltsangabe

The disturbances and abnormalities occurring in the components of the Acetylcholine (ACh) neurocycle are considered one of the main features of cholinergic sicknesses like Parkinson's and Alzheimer's diseases. A fundamental understanding of the ACh neurocycle is therefore very critical in order to design drugs that keep the ACh concentrations in the normal physiological range. In this dissertation, a novel two-enzyme-two-compartment model is proposed in order to explore the bifurcation, dynamics, and chaotic characteristics of the ACh neurocycle. The model takes into consideration the physiological events of the choline uptake into the presynaptic neuron and the ACh release in the postsynaptic neuron. In order to approach more realistic behavior, two complete kinetic mechanisms for enzymatic processes pH-dependent are built: the first mechanism is for the hydrolysis reaction catalyzed by the acetylcholinesterase (AChE) and the other is for the synthesis reaction catalyzed by the cholineacetyltransferase (ChAT).

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Über die Autorin bzw. den Autor

Ibrahim Hassan Mustafa - Associate Professor, Biomedical Engineering Department, Helwan University, Cairo, Egypt.

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Verlag
VDM Verlag
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
3639864204
ISBN 13 
9783639864205
Einband
Taschenbuch
Anzahl der Seiten
236
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Presses Academiques Francophones
customerservice@vdm-vsg.de

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