Molecular Analysis of DNA Rearrangements in the Immune System (Current Topics in Microbiology and Immunology, Band 217) - Softcover

Buch 204 von 322: Current Topics in Microbiology and Immunology
 
9783642501425: Molecular Analysis of DNA Rearrangements in the Immune System (Current Topics in Microbiology and Immunology, Band 217)
Softcover
ISBN 10: 3642501427 ISBN 13: 9783642501425
Verlag: Springer, 2012

Inhaltsangabe

The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon­ stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de­ velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro­ gress in somatic hypermutation.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
Springer
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3642501427
ISBN 13 
9783642501425
Einband
Taschenbuch
Anzahl der Seiten
240
Herausgeber
Jessberger Rolf, Lieber Michael R.
Kontakt zum Hersteller
GPSR Kontakt
ProductSafety@springernature.com

Tiergartenstr. 17
Heidelberg
69121
Deutschland

Weitere beliebte Ausgaben desselben Titels

9783540610373: Molecular Analysis of DNA Rearrangements in the Immune System (Current Topics in Microbiology and Immunology)

Vorgestellte Ausgabe

ISBN 10:  3540610375 ISBN 13:  9783540610373
Verlag: Springer, 1996
Hardcover