DNA Methylation and Cancer (Current Topics in Microbiology and Immunology, Band 249) - Softcover

Buch 73 von 322: Current Topics in Microbiology and Immunology
 
9783642640902: DNA Methylation and Cancer (Current Topics in Microbiology and Immunology, Band 249)
Softcover
ISBN 10: 3642640907 ISBN 13: 9783642640902
Verlag: Springer, 2011

Inhaltsangabe

This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer. Issues related to the mutagenicity of 5-methylcytosine and the increase in the interaction of chemical and physical carcinogens with these residues is discussed. The book summarizes the modulation of viral gene expression and the silencing of tumor suppressor genes and illustrates mechanisms by which the methylation signal is translated into altered chromatin structure. The relationship between DNA methylation and genomic imprinting and cancer, and changes in CpG island methylation which occur in aging are discussed. Mouse model systems have played a key role in our dissection of the relationship between methylation and cancer, and these are also portrayed together with descriptions of new clinical trials in which methylation inhibitors are being used to treat leukemia, myeloid dysplastic syndromes and hemoglobinopathies.

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Verlag
Springer
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3642640907
ISBN 13 
9783642640902
Einband
Taschenbuch
Anzahl der Seiten
188
Herausgeber
Jones P.A., Vogt P.K.
Kontakt zum Hersteller
ProductSafety@springernature.com
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Darmstadt
64293
Deutschland

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Hardcover