Specificity and Function of Clonally Developing T Cells: 126 (Current Topics in Microbiology and Immunology) - Softcover

 
9783642711541: Specificity and Function of Clonally Developing T Cells: 126 (Current Topics in Microbiology and Immunology)
Softcover
ISBN 10: 3642711545 ISBN 13: 9783642711541
Verlag: Springer, 2011

Inhaltsangabe

The international workshop on "Specificity and Function of Clonally Developing T Cells" was held at SchloG Rei­ sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study­ ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen­ tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in long-term culture ; (b) the signals required for the expression of particular patterns of (func­ tional and antigen receptor) phenotypes by T cells which are either freshly explanted in vitro, or maintained in vitro as cloned long-term lines; and (c) the generation of an MHC-restricted T-cell repertoire. In the study of thymocytes emphasis has shifted towards the presumably immature adult/embryonic subset(s) which is (are) devoid of subset-specific differentiation markers (L3T4, Lyt-2). Neither the signal requirement(s) for clonal expansion in vitro of these cells, nor their precursor role for any functional T -cell lineage are as yet unambiguously established. The multiple modes of human T-cell activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were em­ phasized by a number of presentations and raised the ques­ tion of whether these different modes of activation induce different functional activities in individual T-cell clones.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Reseña del editor

The international workshop on "Specificity and Function of Clonally Developing T Cells" was held at SchloG Rei­ sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study­ ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen­ tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in long-term culture ; (b) the signals required for the expression of particular patterns of (func­ tional and antigen receptor) phenotypes by T cells which are either freshly explanted in vitro, or maintained in vitro as cloned long-term lines; and (c) the generation of an MHC-restricted T-cell repertoire. In the study of thymocytes emphasis has shifted towards the presumably immature adult/embryonic subset(s) which is (are) devoid of subset-specific differentiation markers (L3T4, Lyt-2). Neither the signal requirement(s) for clonal expansion in vitro of these cells, nor their precursor role for any functional T -cell lineage are as yet unambiguously established. The multiple modes of human T-cell activation (e.g., via Tp44, T11, T3/Ti molecular complexes) were em­ phasized by a number of presentations and raised the ques­ tion of whether these different modes of activation induce different functional activities in individual T-cell clones.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
Springer
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3642711545
ISBN 13 
9783642711541
Einband
Tapa blanda
Anzahl der Seiten
336
Herausgeber
Fleischer Bernhard, Reimann Jörg, Wagner Hermann
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

Weitere beliebte Ausgaben desselben Titels

9783540165019: Specificity and Function of Clonally Developing T-Cells: 126 (Current Topics in Microbiology and Immunology)

Vorgestellte Ausgabe

ISBN 10:  3540165010 ISBN 13:  9783540165019
Verlag: Springer-Verlag Berlin and Heide..., 1986
Hardcover