Reaction Patterns of the Lymph Node: Part 2 Reactions Associated with Neoplasia and Immune Deficient States: 84/2 (Current Topics in Pathology) - Softcover

 
9783642755248: Reaction Patterns of the Lymph Node: Part 2 Reactions Associated with Neoplasia and Immune Deficient States: 84/2 (Current Topics in Pathology)
Softcover
ISBN 10: 3642755240 ISBN 13: 9783642755248
Verlag: Springer, 2011

Inhaltsangabe

This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im­ munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi­ cant role in this process, which is duly emphasized. Based on appro­ priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec­ tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im­ munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge.

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Reseña del editor

This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im­ munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi­ cant role in this process, which is duly emphasized. Based on appro­ priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec­ tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im­ munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge.

Reseña del editor

The functional processes in the lymph nodes are comprehensively presented in this volume. Particular consideration is given to their immune reactions, the macrophages and plasmocytoid T-cells (plasmocytoid monocytes). All modern methods of immunocytochemistry and electron microscopy, particularly the recent progress in immunoelectron microscopic investigation, are included. The chapters cover all aspects of the subject, so that insight into the newest findings about the lymph nodes and their interactions is given. Special chapters cover lymphocyte circulation, including the structure of the wall of the high endothelial postcapillary venules and the transendothelial pathways of the lymphocytes. One contribution deals with lymph node histopathology in nude rat lymph nodes and shows that many cellular functions proceed normally without the usually dominating T-cell reaction. Two special chapters deal with the macrophages in different compartments; here the major function of dendritic cells is illustrated.

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Verlag
Springer
Erscheinungsdatum
2011
Sprache
Englisch
ISBN 10 
3642755240
ISBN 13 
9783642755248
Einband
Tapa blanda
Anzahl der Seiten
248
Herausgeber
Grundmann E., Vollmer E.
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