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Design & Developement of Floating Tablet of Tolperisone Hydrochloride: Gastroretentive drug delivery system - Softcover

Soni, Ravi; Patel, Mukesh; Patel, Natvarlal

 
9783659136061: Design & Developement of Floating Tablet of Tolperisone Hydrochloride: Gastroretentive drug delivery system
Softcover
ISBN 10: 3659136069 ISBN 13: 9783659136061
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659136069
ISBN 13 
9783659136061
Einband
Taschenbuch
Anzahl der Seiten
160
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland