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Formulation and Characterization of Floating Tablet of Aceclofenac: Hydrodyanamically Balanced System - Softcover

Garg, Shiv Kumar; Gupta, Manish Kumar; Garg, Vinod Kumar

 
9783659136634: Formulation and Characterization of Floating Tablet of Aceclofenac: Hydrodyanamically Balanced System
Softcover
ISBN 10: 3659136638 ISBN 13: 9783659136634
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

The present work focuses on the development of hydrodynamically balanced delivery system of Aceclofenac as a single-unit floating Tablet. Floating effervescent tablets were formulated by various materials like. HPMC, K4M, K 15M, psyllium husk, swelling agent as crospovidone and micro crystalline cellulose and gas generating agent like sodium bicarbonate and citric acid. Floating non effervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers. The prepared floating tablets were evaluated for various Parameter. The formulation was optimized on the basis of in vitro buoyancy and in vitro release By fitting the data into different models, we concluded that the mechanism of release of Aceclofenac from the floating tablet was anomalous diffusion transport and follows zero order kinetics, Stability studies revealed that formulations were stable when stored at different temperatures and the values were within permissible limits. X ray imaging studies results showed that tablet was float more than 8 h in gastric region of the Albino rabbits.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659136638
ISBN 13 
9783659136634
Einband
Taschenbuch
Anzahl der Seiten
164
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Editions Muse
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