Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP - Softcover

Kumar, Prasanth; Patel, Saumya; Pandya, Himanshu

 
9783659153129: Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP
Softcover
ISBN 10: 3659153125 ISBN 13: 9783659153129
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659153125
ISBN 13 
9783659153129
Einband
Taschenbuch
Anzahl der Seiten
104
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Editions Muse
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland