Self Emulsifying Drug Delivery System: Dissolution enhancement of Ibuprofen using Response surface methodology - Softcover

Hossain, Md. Ismail; Akhter, Sadika

Softcover

ISBN 10: 3659174386 ISBN 13: 9783659174384

Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Solubility is considered as a great problem for Ibuprofen hence a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. A 3-level factorial design was carried out to optimize the formulation. The optimized formula contains 24.10 mg Capmul PG8 and 71.02 mg Cremophor EL which releases 27.78%, 44.6% and 74.24% ibuprofen at the mentioned time interval. The present study shows that the Capmul PG8 and Cremophor EL have increased the release profile of capsule Ibuprofen. This attempt, therefore, delivers an alternative strategy in drug product formulation for poorly water soluble drugs. Pharmaceutical technologists, Pharmacists will find it a fruitful approach specially those working on drug delivery.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 3659174386
• ISBN 13: 9783659174384
• Einband: Taschenbuch
• Anzahl der Seiten: 88
• Kontakt zum Hersteller: Nicht verfügbar
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