Potential HIV Reverse Transcriptase Inhibitors: Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors - Softcover

P. Patel, Komal; Patel, Jimish R.; Giridhar, Rajani

 
9783659184710: Potential HIV Reverse Transcriptase Inhibitors: Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors
Softcover
ISBN 10: 3659184713 ISBN 13: 9783659184710
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659184713
ISBN 13 
9783659184710
Einband
Taschenbuch
Anzahl der Seiten
68
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Edicoes Nosso Conhecimento
customerservice@vdm-vsg.de

SIA
Riga
1039
Litauen