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Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6’-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6’)-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6’) inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group.
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Über die Autorin bzw. den Autor
Eric Habib first got his bachelor's degree in biochemistry at McGill University in 2008. He later changed to more applied research, obtaining his master's degree from McGill's chemistry department in 2013 in the groups of Profs Auclair and Mittermaier. He is now pursuing studies in material science at Université de Montréal with Prof Julian Zhu.
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Designing an Inhibitor for AAC(6')-Ii
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LAP LAMBERT Academic Publishing Mär 2014, 2014
ISBN 10: 3659199842
ISBN 13: 9783659199844
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group. 156 pp. Englisch. Bestandsnummer des Verkäufers 9783659199844
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Designing an Inhibitor for AAC(6 )-Ii
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Habib EricEric Habib first got his bachelor s degree in biochemistry at McGill University in 2008. He later changed to more applied research, obtaining his master s degree from McGill s chemistry department in 2013 in the groups of P. Bestandsnummer des Verkäufers 5139072
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Designing an Inhibitor for Aac(6')-II
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Designing an Inhibitor for Aac(6')-II
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Designing an Inhibitor for Aac(6')-II
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Designing an Inhibitor for AAC(6¿)-Ii : Fragment-based Drug Design using SAR by NMR
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group. Bestandsnummer des Verkäufers 9783659199844
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Designing an Inhibitor for AAC(6')-Ii
Verlag:
LAP LAMBERT Academic Publishing Mär 2014, 2014
ISBN 10: 3659199842
ISBN 13: 9783659199844
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase. Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates that was found to be potent inhibitors of AAC(6')-Ii, but lacked activity in cell-based assays. In order to combat aminoglycoside resistance, this book aims at developing a new class of AAC(6') inhibitors using fragment-based drug design with NMR-based assays for the initial screening. This approach has the advantage of potentially identifying new structural scaffolds that are fundamentally different from those that have been previously developed in the group.OmniScriptum SRL, Str. Armeneasca 28/1, office 1, 2012 Chisinau 156 pp. Englisch. Bestandsnummer des Verkäufers 9783659199844
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Designing an Inhibitor for AAC(6')-Ii | Fragment-based Drug Design using SAR by NMR
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ISBN 13: 9783659199844
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Taschenbuch. Zustand: Neu. Designing an Inhibitor for AAC(6')-Ii | Fragment-based Drug Design using SAR by NMR | Eric Habib | Taschenbuch | 156 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783659199844 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 105354772
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