Formulation and Characterization of Aceclofenac Microsphere: Aceclofenac Microsphere - Softcover

Verma, Sofiya; Chaurasia, Sandhya; Asati, Ashok

Softcover

ISBN 10: 3659202320 ISBN 13: 9783659202322

Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

The purpose of this research was to prepare and characterize Aceclofenac microsphere of guar gum polymer for the application of inflammation. Method: - The microsphere were prepared by using emulsification method using starch cross-linked agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. Result:-The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The stability study was conducted to conform the stability of prepared microsphere. In-vitro drug release study was performed in both simulated gastrointestinal fluid medium and rat cecal content of different pH. Conclusion:-The prepared Aceclofenac microsphere has the potential for delaying the release of drug.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 3659202320
• ISBN 13: 9783659202322
• Einband: Taschenbuch
• Anzahl der Seiten: 96
• Kontakt zum Hersteller: Nicht verfügbar
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