Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin: Gastro - retentive floating matrix tablets - Softcover

Dudhipala, Narendar; Reddy, Sunil; Yamsani, Madhusudan Rao

 
9783659238147: Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin: Gastro - retentive floating matrix tablets
Softcover
ISBN 10: 3659238147 ISBN 13: 9783659238147
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up.

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Über die Autorin bzw. den Autor

Mr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AndraPradesh, India. He completed His B.Pharm and M.Pharm from Kakatiya University. He received "Research Excellence awrad" in 63rd IPC.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659238147
ISBN 13 
9783659238147
Einband
Taschenbuch
Anzahl der Seiten
64
Kontakt zum Hersteller
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