Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging: A theoretical and experimental study of near-filed and far-field CARS microscopy for biomedical imaging - Softcover

Lin, Jian

 
9783659289132: Coherent Anti-Stokes Raman Scattering (CARS) Microscopy for Bioimaging: A theoretical and experimental study of near-filed and far-field CARS microscopy for biomedical imaging
Softcover
ISBN 10: 3659289132 ISBN 13: 9783659289132
Verlag: LAP LAMBERT Academic Publishing, 2012

Inhaltsangabe

Coherent anti-Stokes Raman scattering (CARS) microscopy is a nonlinear Raman imaging technique that has received great attention for biological and biomedical imaging due to its ability of real-time, nonperturbative chemical mapping of live unstained cells and tissue based on molecular vibrations. However, the strong nonresonant background reduces the image contrast and sensitivity of CARS imaging. Its spatial resolution is limited by light diffraction. This research has systematically studied the near-field (NF) effects of nanoparticle sizes, orientations, polarization of excitations on NF-CARS imaging using FDTD method, and has developed a radially polarized near-field tip-enhanced (TE) CARS system for high-resolution vibrational imaging and a unique annular-aperture detection scheme for suppressing the solvent background. The novel TE-CARS technique and the multimodal nonlinear optical microscopy imaging platform developed in this work have great potential to provide new insights into better understanding of morphological, biochemical and biomolecular changes associated with tissue and cell pathologic transformation at the tissue, cellular and molecular levels without labeling.

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Über die Autorin bzw. den Autor

Lin Jian is a research fellow at the Department of Bioengineering in National University of Singapore. He received his Ph.D. degree from National University of Singapore. His main research field is nonlinear optical microscopy for biomedical imaging.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
3659289132
ISBN 13 
9783659289132
Einband
Taschenbuch
Anzahl der Seiten
120
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Edicoes Nosso Conhecimento
customerservice@vdm-vsg.de

SIA
Riga
1039
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