Development of Novel Indolyl-derived Biologically Active Compounds: Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer) - Softcover

El Sayed, Mardia

 
9783659320712: Development of Novel Indolyl-derived Biologically Active Compounds: Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)
Softcover
ISBN 10: 3659320714 ISBN 13: 9783659320712
Verlag: LAP LAMBERT Academic Publishing, 2015

Inhaltsangabe

MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the β-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a “superbug” because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or standard. We have shown for the first time that the cycloalkanoindoles,bis-indolobenzocarbazoles and the oxidized bis-indolylmethenes inhibited growth of drug resistant MRSA either standard or isolate and other Gram-positive bacteria at low concentrations. Some of these novel bis- and tris-indolyl compounds described in this work have been screened in the national cancer institute (NCI) in USA for one and five dose that showed the highest antipoliferative activity in a nanomolar scale towards the selected cancers cell lines (Non small lung: NCIeH460, Ovarian: OVCAR-4 and Breast: MCF).

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Über die Autorin bzw. den Autor

Author is Dr/Mardia Telep El Sayed, Egyptian researcher at National Research Centre, Applied Organic Chemistry Department. In 2009 she started her PhD scholarship in Synthetic Organic Chemistry/ Martin Luthr University Halle/ Germany and recieved her PhD in April 2013. She has BSc and MSc in Organic Chemistry from Egyptian Universties.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2015
Sprache
Englisch
ISBN 10 
3659320714
ISBN 13 
9783659320712
Einband
Taschenbuch
Anzahl der Seiten
312
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
JustFiction Edition
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
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