Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer - Softcover

Jambukiya, Vipul; Parmar, Ramesh; Sheth, N. R.

 
9783659337536: Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer
Softcover
ISBN 10: 3659337536 ISBN 13: 9783659337536
Verlag: LAP LAMBERT Academic Publishing, 2013

Inhaltsangabe

Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU

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Über die Autorin bzw. den Autor

Vipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under the Guidance of Dr. J. K. Patel.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
3659337536
ISBN 13 
9783659337536
Einband
Taschenbuch
Anzahl der Seiten
92
Kontakt zum Hersteller
Editions Vie
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland